Journal article
Lithium-doped β-tricalcium phosphate: Effects on physical, mechanical and in vitro osteoblast cell-material interactions
Journal of biomedical materials research. Part B, Applied biomaterials, Vol.105(2), pp.391-399
02/2017
Handle:
https://hdl.handle.net/2376/115909
PMID: 26525914
Abstract
In this work, we have investigated the effects of lithium (Li) dopant at different concentrations and sintering temperatures on the physical and mechanical properties of β-tricalcium phosphate (β-TCP). Our results showed that Li addition at concentrations of 0.65 and 1.0 wt % inhibits the β-TCP to α-TCP phase transformation. 0.15 wt % Li addition resulted in grain growth and extensive liquid phase was formed at higher concentrations. At 1150°C, compressive strength of β-TCP increased from 138.7 ± 19.9 MPa to 170.9 ± 29.8 MPa with the addition of 0.15 wt % Li. Addition of higher amounts of Li decreased the compressive strength and the lowest compressive strength of 99.8 ± 13.7 MPa was found in samples containing 1.0 wt % Li. After 3 days of culture, osteoblast cells grew to confluence on samples containing 0.65 and 1.0 wt % Li. Cells grew to confluence on all doped samples after 11 days of culture and optical cell density was 4-5 folds higher on 0.15 and 1.0 wt % Li-doped TCP samples. Our results show that both Li content and sintering temperature have significant influence toward physicochemical and mechanical properties of β-TCP which affects the osteoblast cell-materials interaction in Li-doped TCP scaffolds. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 391-399, 2017.
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Details
- Title
- Lithium-doped β-tricalcium phosphate: Effects on physical, mechanical and in vitro osteoblast cell-material interactions
- Creators
- Sahar Vahabzadeh - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, 99164-2920Vaughn Kohsei Hack - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, 99164-2920Susmita Bose - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington, 99164-2920
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, Vol.105(2), pp.391-399
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- United States
- Identifiers
- 99900547567701842
- Language
- English
- Resource Type
- Journal article