Journal article
Local Use-Dependent Sleep; Synthesis of the New Paradigm
Current topics in medicinal chemistry, Vol.11(19), pp.2490-2492
09/01/2011
Handle:
https://hdl.handle.net/2376/117711
PMCID: PMC3248786
PMID: 21906015
Abstract
The logic and potential mechanisms for a new paradigm, the local use-dependent view of sleep as a distributed dynamic process in brain, are presented. This new paradigm is needed because the current dominant top-down imposition of sleep on the brain by sleep regulatory centers is either silent or is of inadequate explanatory value for many well-known sleep phenomena, e.g. sleep inertia. Two mechanistic falsifiable hypotheses linking sleep to cell use and the emergence of sleep/wake states are presented. These hypotheses are not mutually exclusive and both firmly link sleep to activity-dependent epigenetic brain plasticity and the need to integrate and balance waking activity induced-network connectivity changes. The views presented herein emphasize the inseparability of sleep mechanisms from a connectivity sleep function.
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Details
- Title
- Local Use-Dependent Sleep; Synthesis of the New Paradigm
- Creators
- James M Krueger - WWAMI Medical Education Program and the Sleep and Performance Research Center, Washington State University, Spokane WA 99210-1495, USAGiulio Tononi - University of Wisconsin Madison, School of Medicine and Public Health, Department of Psychiatry, 6001 Research Park Blvd., Madison, WI 53719, USA
- Publication Details
- Current topics in medicinal chemistry, Vol.11(19), pp.2490-2492
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Grant note
- R01 NS031453-18 || NS / National Institute of Neurological Disorders and Stroke : NINDS R01 NS025378-18 || NS / National Institute of Neurological Disorders and Stroke : NINDS
- Identifiers
- 99900548243001842
- Language
- English
- Resource Type
- Journal article