Local sleep

James M Krueger; Joseph T Nguyen; Cheryl J Dykstra-Aiello; Ping Taishi

doi:10.1016/j.smrv.2018.10.001

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Journal article

Open access

Peer reviewed

Local sleep

James M Krueger, Joseph T Nguyen, Cheryl J Dykstra-Aiello and Ping Taishi

Sleep medicine reviews, Vol.43, pp.14-21

02/2019

DOI: https://doi.org/10.1016/j.smrv.2018.10.001

Handle:

https://hdl.handle.net/2376/110351

PMCID: PMC6351167

PMID: 30502497

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https://doi.org/10.1016/j.smrv.2018.10.001View

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Abstract

Sleep Deprivation

Animals

Humans

Neuroglia - physiology

Neurons - physiology

Homeostasis

Models, Neurological

Sleep - physiology

In Vitro Techniques

Brain - physiology

Nerve Net - physiology

The historic sleep regulatory paradigm invokes "top-down" imposition of sleep on the brain by sleep regulatory circuits. While remaining conceptually useful, many sleep phenomena are difficult to explain using that paradigm, including, unilateral sleep, sleep-walking, and poor performance after sleep deprivation. Further, all animals sleep after non-lethal brain lesions, regardless of whether the lesion includes sleep regulatory circuits, suggesting that sleep is a fundamental property of small viable neuronal/glial networks. That small areas of the brain can exhibit non-rapid eye movement sleep-like states is summarized. Further, sleep-like states in neuronal/glial cultures are described. The local sleep states, whether in vivo or in vitro, share electrophysiological properties and molecular regulatory components with whole animal sleep and exhibit sleep homeostasis. The molecular regulatory components of sleep are also involved in plasticity and inflammation. Like sleep, these processes, are initiated by local cell-activity dependent events, yet have at higher levels of tissue organization whole body functions. While there are large literatures dealing with local initiation and regulation of plasticity and inflammation, the literature surrounding local sleep is in its infancy and clinical applications of the local sleep concept are absent. Regardless, the local use-dependent sleep paradigm can advise and advance future research and clinical applications.

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Title: Local sleep
Creators: James M Krueger - Department of Integrative Physiology and Neurobiology, College of Veterinary Medicine, Spokane, WA, USA. Electronic address: j.krueger@wsu.edu
Joseph T Nguyen - Department of Integrative Physiology and Neurobiology, College of Veterinary Medicine, Spokane, WA, USA
Cheryl J Dykstra-Aiello - Department of Integrative Physiology and Neurobiology, College of Veterinary Medicine, Spokane, WA, USA
Ping Taishi - Department of Integrative Physiology and Neurobiology, College of Veterinary Medicine, Spokane, WA, USA
Publication Details: Sleep medicine reviews, Vol.43, pp.14-21
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: England
Grant note: R01 NS025378 / NINDS NIH HHS R21 NS096250 / NINDS NIH HHS
Identifiers: 99900547180501842
Language: English
Resource Type: Journal article