Journal article
Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy
Epilepsy & behavior, Vol.20(3), pp.545-549
03/2011
Handle:
https://hdl.handle.net/2376/106303
PMID: 21333607
Abstract
Depression is associated with higher rates of suicide and lower quality of life in individuals with epilepsy. We previously published the 12-month outcome from our randomized clinical trial of PEARLS (Ciechanowski P, Chaytor N, Miller J, et al. Epilepsy Behav. Epub 5 July 2010). The purpose of this study was to determine the long-term effectiveness of PEARLS, a home-based collaborative care intervention consisting of problem-solving treatment, behavioral activation, and psychiatric consultation, in individuals with epilepsy. Patients were randomly assigned to PEARLS (N=40) or usual care (N=40), and assessed at baseline and 6, 12, and 18months. Patients assigned to PEARLS achieved lower depression severity (P<0.05) (Hopkins Symptoms Checklist-20), lower suicidal ideation (P<0.02), and better emotional well being (QOLIE-31) (P<0.02) over 18months, compared with patients given the usual care. The PEARLS program significantly reduces depressive symptoms in adults with epilepsy, and this effect is maintained for 18months after baseline and for more than 1year after completion of home visits.
► Long-term outcomes of depression treatment in epilepsy have not been reported. ► The PEARLS intervention resulted in reduction in depression symptoms. ► The PEARLS intervention resulted in reduction in suicidal ideation. ► The PEARLS intervention resulted in improvement in emotional well-being. ► This improvement persisted to the 18-month follow-up.
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Details
- Title
- Long-term outcomes from the PEARLS randomized trial for the treatment of depression in patients with epilepsy
- Creators
- Naomi Chaytor - Department of Neurology, University of Washington School of Medicine, Seattle, WA, USAPaul Ciechanowski - Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USAJohn W Miller - Department of Neurology, University of Washington School of Medicine, Seattle, WA, USARobert Fraser - Department of Neurology, University of Washington School of Medicine, Seattle, WA, USAJoan Russo - Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USAJurgen Unutzer - Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USAFrank Gilliam - Department of Neurology, Geisinger Health System, Danville, PA, USA
- Publication Details
- Epilepsy & behavior, Vol.20(3), pp.545-549
- Academic Unit
- Medical Education and Clinical Science, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546751801842
- Language
- English
- Resource Type
- Journal article