Journal article
Lovastatin release from polycaprolactone coated β-tricalcium phosphate: Effects of pH, concentration and drug–polymer interactions
Materials Science & Engineering C, Vol.33(6), pp.3121-3128
08/01/2013
Handle:
https://hdl.handle.net/2376/111933
PMCID: PMC3767773
PMID: 23706191
Abstract
The approach of local drug delivery from polymeric coating is currently getting significant attention for both soft and hard tissue engineering applications for sustained and controlled release. The chemistry of the polymer and the drug, and their interactions influence the release kinetics to a great extent. Here, we examine lovastatin release behaviour from polycaprolactone (PCL) coating on β-tricalcium phosphate (β-TCP). Lovastatin was incorporated into biodegradable water insoluble PCL coating. A burst and uncontrolled lovastatin release was observed from bare β-TCP, whereas controlled and sustained release was observed from PCL coating. A higher lovastatin release was observed pH7.4 as compared to pH5.0. Effect of PCL concentration on lovastatin release was opposite at pH7.4 and 5.0. At pH5.0 lovastatin release was decreased with increasing PCL concentration, whereas release was increased with increasing PCL concentration at pH7.4. High Ca2+ ion concentration due to high solubility of β-TCP and degradation of PCL coating were observed at pH5.0 compared to no detectable Ca2+ ion release and visible degradation of PCL coating at pH7.4. The hydrophilic–hydrophobic and hydrophobic–hydrophobic interactions between lovastatin and PCL were found to be the key factors controlling the diffusion dominated release kinetics of lovastatin from PCL coating over dissolution and degradation processes. Understanding the lovastatin release chemistry from PCL will be beneficial for designing drug delivery devices from polymeric coating or scaffolds.
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•Lovastatin release chemistry from PCL coated β-TCP was examined.•Incorporation of lovastatin into PCL coating contributed to a controlled release.•PCL amount in the coating and pH of the release media affected the release kinetics.•Drug–polymer hydrophilicity and hydrophobicity were the dominant factors.
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Details
- Title
- Lovastatin release from polycaprolactone coated β-tricalcium phosphate: Effects of pH, concentration and drug–polymer interactions
- Creators
- Solaiman Tarafder - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USAKelly Nansen - Gene and Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, WA, USASusmita Bose - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
- Publication Details
- Materials Science & Engineering C, Vol.33(6), pp.3121-3128
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Elsevier B.V
- Identifiers
- 99900547642401842
- Language
- English
- Resource Type
- Journal article