Journal article
Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis
International journal of epidemiology, Vol.45(3), pp.835-845
06/2016
Handle:
https://hdl.handle.net/2376/114949
PMCID: PMC5005938
PMID: 26228584
Abstract
Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers.
We conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0-3, >3-5, >5-10 cigarettes per day.
Smoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.
Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.
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Details
- Title
- Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis
- Creators
- Julien Berthiller - International Agency for Research on Cancer, Lyon, France, Pôle Information Médicale Evaluation Recherche, Hospices Civils de Lyon, FrancePhilip Lazarus - Washington State University College of Pharmacy, Spokane, WA, USAKurt Straif - International Agency for Research on Cancer, Lyon, FranceAntonio Agudo - Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, Barcelona, SpainWolfgang Ahrens - Bremen Institute for Prevention Research and Social Medicine (BIPS), Bremen, GermanyAlexandre Bezerra Dos Santos - Instituto do Câncer do Estado de Sao Paulo (ICESP), Sao Paulo, BrazilStefania Boccia - Institute of Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Rome, Italy, L'Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, ItalyGabriella Cadoni - Head and Neck Surgery Department, Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Rome, ItalyCristina Canova - University of Padua, Padua, ItalyXavier Castellsague - Catalan Institute of Oncology (ICO)-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain, CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona, SpainChu Chen - Fred Hutchinson Cancer Research Center, Seattle, WA, USADavid Conway - Dental School, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UKMaria Paula Curado - International Prevention Research Institute, Lyon, FranceLuigino Dal Maso - Aviano Cancer Centre, Aviano, ItalyAlexander W Daudt - Hospital de Clinicas de Porto Alegre, Porto Alegre, BrazilEleonora Fabianova - Regional Authority of Public Health, Banska Bystrica, SlovakiaLeticia Fernandez - Institute of Oncology and Radiobiology, La Havana, Cuba, Instituto do Câncer do Estado de Sao Paulo (ICESP), Sao Paulo, BrazilSilvia Franceschi - International Agency for Research on Cancer, Lyon, FranceErica E Fukuyama - Instituto do Câncer do Estado de Sao Paulo (ICESP), Sao Paulo, BrazilRichard B Hayes - Division of Epidemiology, New York University School Of Medicine, New York, NY, USAClaire Healy - Trinity College School of Dental Science, Dublin, IrelandRolando Herrero - International Agency for Research on Cancer, Lyon, FranceIvana Holcatova - Institute of Hygiene and Epidemiology, Prague, Czech RepublicKarl Kelsey - Brown University, Providence, RI, USAKristina Kjaerheim - Cancer Registry of Norway, Oslo, NorwaySergio Koifman - Escola Nacional de Saude Publica, Fundacao Oswaldo Cruz, Rio de Janeiro, BrazilPagona Lagiou - University of Athens School of Medicine, Athens, GreeceCarlo La Vecchia - Istituto Di Ricovero e Cura a Carattere Scientific IRCCS, Milan, ItalyFabio Levi - Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital (CHUV), Lausanne, SwitzerlandJolanta Lissowska - M. Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Prevention, Warsaw, PolandTatiana Macfarlane - University of Aberdeen Dental School, Aberdeen, UKDana Mates - National Institute of Public Health, Bucharest, RomaniaMichael McClean - Boston University School of Public Health, Boston, MA, USAAna Menezes - Universidade Federal de Pelotas, Pelotas, BrazilFranco Merletti - University of Turin, Turin, ItalyHal Morgenstern - Departments of Epidemiology, Environmental Health Sciences, and Urology, Schools of Public Health and Medicine, and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USAJoshua Muscat - Penn State College of Medicine, Hershey, PA, USAAndrew F Olshan - UNC School of Public Health, Chapel Hill, NC, USAMark Purdue - National Cancer Institute, National Institutes of Health, Bethesda, MD, USAHeribert Ramroth - University of Heidelberg, Heidelberg, GermanyPeter Rudnai - National Institute of Environmental Health, Budapest, HungaryStephen M Schwartz - Fred Hutchinson Cancer Research Center, Seattle, WA, USADiego Serraino - Aviano Cancer Centre, Aviano, ItalyOxana Shangina - Cancer Research Centre, Moscow, RussiaElaine Smith - College of Public Health, University of Iowa, Iowa City, IA, USAErich M Sturgis - UT-M.D. Anderson Cancer Center, Houston, TX, USANeonila Szeszenia-Dabrowska - Institute of Occupational Medicine, Lodz, PolandPeter Thomson - University of Newcastle, Newcastle, UKThomas L Vaughan - Fred Hutchinson Cancer Research Center, Seattle, WA, USAMarta Vilensky - Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, ArgentinaQingyi Wei - UT-M.D. Anderson Cancer Center, Houston, TX, USADeborah M Winn - National Cancer Institute, National Institutes of Health, Bethesda, MD, USAVictor Wünsch-Filho - Universidade de Sao Paulo, Sao Paulo, BrazilZuo-Feng Zhang - UCLA School of Public Health, Los Angeles, CA, USAAriana Znaor - Croatian National Cancer Registry, Zagreb, CroatiaGilles Ferro - International Agency for Research on Cancer, Lyon, FrancePaul Brennan - International Agency for Research on Cancer, Lyon, FrancePaolo Boffetta - Tisch Cancer Institute and Institute of Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY, USAMia Hashibe - Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA and University of Utah School of Medicine, Salt Lake City, UT, USAYuan-Chin Amy Lee - University of Utah School of Medicine, Salt Lake City, UT, USA amy.lee@utah.edu
- Publication Details
- International journal of epidemiology, Vol.45(3), pp.835-845
- Academic Unit
- Department of Pharmaceutical Sciences
- Publisher
- England
- Grant note
- R03 CA113157 / NCI NIH HHS P2C HD050924 / NICHD NIH HHS T32 CA009142 / NCI NIH HHS R01 DA011386 / NIDA NIH HHS R03 DE016611 / NIDCR NIH HHS P01 CA068384 / NCI NIH HHS R01 DE013110 / NIDCR NIH HHS R03 CA077954 / NCI NIH HHS R21 ES011667 / NIEHS NIH HHS P50 CA090388 / NCI NIH HHS R01 DE013158 / NIDCR NIH HHS R01 CA100679 / NCI NIH HHS R01 ES025460 / NIEHS NIH HHS P30 ES010126 / NIEHS NIH HHS R01 CA078609 / NCI NIH HHS R01 ES011740 / NIEHS NIH HHS R01 CA048996 / NCI NIH HHS R01 CA100264 / NCI NIH HHS K07 CA104231 / NCI NIH HHS U01 CA096134 / NCI NIH HHS
- Identifiers
- 99900547791401842
- Language
- English
- Resource Type
- Journal article