Journal article
Lung Cancer Risk in White and Black Americans
Annals of epidemiology, Vol.13(4), pp.294-302
2003
Handle:
https://hdl.handle.net/2376/112969
PMID: 12684197
Abstract
PURPOSE: To test whether differences in smoking-related lung cancer risks in blacks and whites can explain why lung cancer incidence is greater in black males than in white males but about equal in black and white females, given that a greater proportion of blacks are smokers, but smoke far fewer cigarettes per day than do whites.
METHODS: A hospital-based case-control study was conducted between 1984 and 1998 that included interviews with 1,710 white male and 1,321 white female cases of histologically confirmed lung cancer, 254 black male and 163 black female cases, and 8,151 controls. Relative risks were estimated via odds ratios using logistic regression, adjusted for age, education, and body mass index.
RESULTS. We confirmed prior reports that smoking prevalence is higher but overall dosage is lower among blacks. Overall ORs were similar for blacks and whites, except among the heaviest smoking males (21+ cigarettes per day or 37.5 pack–years), in whom ORs for blacks were considerably greater than for whites. Long-term benefits of cessation were similar for white and black ex-smokers. Smokers of menthol flavored cigarettes were at no greater risk for lung cancer than were smokers of unflavored brands.
CONCLUSIONS. Lung cancer risks were similar for whites and blacks with similar smoking habits, except possibly for blacks who were very heavy smokers; this sub-group is unusual in the general population of African American smokers. Explanations of racial disparities in lung cancer risk may need to account for modifying factors including type of cigarette (yield, mentholation), diet, occupation, and host factors such as ability to metabolize mainstream smoke carcinogens.
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Details
- Title
- Lung Cancer Risk in White and Black Americans
- Creators
- Steven D Stellman - American Health Foundation, One Dana Road, Valhalla, NY 10595 USAYu Chen - Department of Epidemiology, Mailman School of Public Health, Columbia University, 630 West 168th Street, PH-18, New York, NY 10032 USAJoshua E Muscat - Division of Epidemiology, American Health Foundation, One Dana Road, Valhalla, NY 10595 USAIrjana V Djordjevic - Tobacco Control Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Boulevard, EPN 4039, Rockville, MD 20852 USAJohn P Richie - Division of Nutritional Carcinogenesis, American Health Foundation, One Dana Road, Valhalla, NY 10595 USAPhilip Lazarus - Divisions of Cancer Control and Mol. Oncology, H. Lee Moffitt Cancer Center, MRC-2E, 12902 Magnolia Drive, Tampa, FL 33612 USASeth Thompson - Bristol-Meyers Squibb, 5 Research Parkway, Wallingford, CT 06492 USANasser Altorki - Division of Thoracic Surgery, New York Presbyterian Hospital, 525 East 68th Street, New York, NY 10021 USAMarianne Berwick - Department of Epidemiology & Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USAMarc L Citron - ProHealth, Inc., 2800 Marcus Avenue, Lake Success, NY 11042 USASusan Harlap - Dept. of Obstetrics and Gynecology and Kaplan Cancer Center, NYU Medical Center—Room NBV-9E-2, 550 First Avenue, New York, NY 10016 USATajinder B Kaur - Dept. of Obstetrics and Gynecology, Temple University Hospital, 3401 N. Broad Street, Philadelphia, PA 19140 USAAlfred I Neugut - Department of Epidemiology, Mailman School of Public Health, Columbia University, 630 West 168th Street, PH-18, New York, NY 10032 USASara Olson - Department of Epidemiology & Biostatistics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021 USAJohn M Travaline - Pulmonary Division, Temple University School of Medicine, 3400 N. Broad Street, Philadelphia, PA 19140 USAPhilip Witorsch - Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC 20007 USAZuo-Feng Zhang - Department of Epidemiology, UCLA School of Public Health, 71-225 CHS, Box 951772, 10833 Le Conte Avenue, Los Angeles, CA 90095-1772 USA
- Publication Details
- Annals of epidemiology, Vol.13(4), pp.294-302
- Academic Unit
- Pharmaceutical Sciences, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547528201842
- Language
- English
- Resource Type
- Journal article