Journal article
Lymphocyte alterations in zinc-deficient calves with lethal trait A46
Veterinary immunology and immunopathology, Vol.21(3), pp.239-248
1989
Handle:
https://hdl.handle.net/2376/117012
PMID: 2800326
Abstract
Lymphocyte numbers and activities were evaluated at 2, 4, 8 and 12 weeks of age in two calves with lethal trait A46 (A46), a genetic disorder affecting intestinal zinc absorption. Plasma zinc concentrations declined to subnormal by 3 weeks of age, after which anorexia, diarrhea, alopecia and hyperkeratosis occurred. Lymphocyte response to phytohemagglutinin-P (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM) stimulation was variably reduced. CD4
+ T-lymphocytes were subnormal on at least one observation period following onset of zinc deficiency, and relative numbers of B lymphocytes were decreased at 8 weeks. Secondary antibody responses to bacteriophage φX 174 were significantly reduced. The results demonstrate that calves homozygous for the A46 trait have normal numbers of functional lymphocyte subpopulations at birth, and that the activity of their lymphocytes is altered once the calves become zinc deficient.
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Details
- Title
- Lymphocyte alterations in zinc-deficient calves with lethal trait A46
- Creators
- Lance E Perryman - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040 U.S.ADana R Leach - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040 U.S.AWilliam C Davis - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040 U.S.AW.Duane Mickelsen - Department of Veterinary Clinical Medicine and Surgery, Washington State University, Pullman, WA 99164-7040 U.S.ASamuel R Heller - Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 U.S.AHans D Ochs - Department of Pediatrics, University of Washington School of Medicine, Seattle, WA 98195 U.S.AJohn A Ellis - Department of Veterinary Sciences, The University of Wyoming, Laramie, WY 82070 U.S.AErik Brummerstedt - Department of Veterinary Pathology, The Royal Veterinary and Agricultural University, Copenhagen Denmark
- Publication Details
- Veterinary immunology and immunopathology, Vol.21(3), pp.239-248
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900548288901842
- Language
- English
- Resource Type
- Journal article