Journal article
Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells
Nanoscale, Vol.11(17), pp.8458-8463
04/25/2019
PMID: 30994690
Abstract
Formaldehyde (FA) is involved in many biological processes and is closely connected with many diseases including Alzheimer's disease and cancer. Therefore, methods for sensitive and selective detection of FA in living cells are highly demanded. As a new class of carbon nanomaterials, carbon dots (CDs) have attracted great attention owing to their robust photostability, good biocompatibility and environmental friendliness. In this manuscript, the first lysosome-targeted CDs for ratiometric fluorescence detection of FA were efficiently prepared from dexamethasone and 1,2,4,5-tetraaminobenzene through the microwave-assisted hydrothermal method. These CDs show highly selective and sensitive sensing ability towards FA with fast response and great changes of ratio values. The CDs exhibit robust photostability and good biocompatibility and were successfully employed in ratiometric fluorescence bioimaging of FA fluctuations in lysosomes of living cells, which demonstrates their great practicability in FA-related bioanalysis and biological studies.
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Details
- Title
- Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells
- Creators
- Haifang Liu - Zhengzhou UniversityYuanqiang Sun - Zhengzhou UniversityZhaohui Li - Zhengzhou UniversityJie Yang - Zhengzhou UniversityAaron Albert Aryee - Zhengzhou UniversityLingbo Qu - Zhengzhou UniversityDan Du - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- Nanoscale, Vol.11(17), pp.8458-8463
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Royal Soc Chemistry
- Number of pages
- 6
- Grant note
- 19A150048 / Key Scientific Research Project in Universities of Henan Province 2017M620302; 2018T110736 / China Postdoctoral Science Foundation 2017GGJS007 / Foundation for University Key Teacher by Henan Province 21708035 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Identifiers
- 99901227642301842
- Language
- English
- Resource Type
- Journal article