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CC BY V4.0, Open Access
Journal article
MODELING THE ENDOCRINE CONTROL OF VITELLOGENIN PRODUCTION IN FEMALE RAINBOW TROUT
Mathematical biosciences and engineering : MBE, Vol.11(3), pp.621-639
06/2014
Handle:
https://hdl.handle.net/2376/102641
PMCID: PMC4674810
PMID: 24506554
Abstract
The rainbow trout endocrine system is sensitive to changes in annual day length, which is likely the principal environmental cue controlling its reproductive cycle. This study focuses on the endocrine regulation of vitellogenin (Vg) protein synthesis, which is the major egg yolk precursor in this fish species. We present a model of Vg production in female rainbow trout which incorporates a biological pathway beginning with sex steroid estradiol-17β levels in the plasma and concluding with Vg secretion by the liver and sequestration in the oocytes. Numerical simulation results based on this model are compared with experimental data for estrogen receptor mRNA, Vg mRNA, and Vg in the plasma from female rainbow trout over a normal annual reproductive cycle. We also analyze the response of the model to parameter changes. The model is subsequently tested against experimental data from female trout under a compressed photoperiod regime. Comparison of numerical and experimental results suggests the possibility of a time-dependent change in oocyte Vg uptake rate. This model is part of a larger effort that is developing a mathematical description of the endocrine control of reproduction in female rainbow trout. We anticipate that these mathematical and computational models will play an important role in future regulatory toxicity assessments and in the prediction of ecological risk.
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Details
- Title
- MODELING THE ENDOCRINE CONTROL OF VITELLOGENIN PRODUCTION IN FEMALE RAINBOW TROUT
- Creators
- Kaitlin Sundling - Biophysics Program and Medical Scientist Training Program, University of Wisconsin, Madison, WI 53706, USAGheorghe Craciun - Department of Mathematics and Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USAIrvin Schultz - Battelle Pacific Northwest National Laboratory, Marine Sciences Laboratory, Sequim, WA 98382, USASharon Hook - Battelle Pacific Northwest National Laboratory, Marine Sciences Laboratory, Sequim, WA 98382, USAJames Nagler - Department of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, ID 83844, USATim Cavileer - Department of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, ID 83844, USAJoseph Verducci - Department of Statistics, Ohio State University, Columbus, OH 43210, USAYushi Liu - The Ohio State UniversityJonghan Kim - Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USAWilliam Hayton - Division of Pharmaceutics, Ohio State University, Columbus, OH 43210, USA
- Publication Details
- Mathematical biosciences and engineering : MBE, Vol.11(3), pp.621-639
- Academic Unit
- School of Biological Sciences
- Publisher
- Amer Inst Mathematical Sciences-Aims
- Number of pages
- 19
- Grant note
- DMS-054069377 / National Science Foundation; National Science Foundation (NSF) T32GM08349 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA University of Wisconsin Medical Scientist Training Program T32GM008692 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Identifiers
- 99900546566601842
- Language
- English
- Resource Type
- Journal article