Mechanical degradation of TiO2 nanotubes with and without nanoparticulate silver coating

Anish Shivaram; Susmita Bose; Amit Bandyopadhyay

doi:10.1016/j.jmbbm.2016.02.028

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Mechanical degradation of TiO2 nanotubes with and without nanoparticulate silver coating

Journal article

Open access

Peer reviewed

Mechanical degradation of TiO2 nanotubes with and without nanoparticulate silver coating

Anish Shivaram, Susmita Bose and Amit Bandyopadhyay

Journal of the mechanical behavior of biomedical materials, Vol.59, pp.508-518

06/2016

DOI: https://doi.org/10.1016/j.jmbbm.2016.02.028

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https://hdl.handle.net/2376/107295

PMCID: PMC4860156

PMID: 27017285

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https://doi.org/10.1016/j.jmbbm.2016.02.028View

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Abstract

Nanotubes - chemistry

Animals

Biocompatible Materials - chemistry

Humans

Metal Nanoparticles - chemistry

Surface Properties

Cells, Cultured

Silver - chemistry

Titanium - chemistry

Horses

Materials Testing

Osteoblasts - cytology

The primary objective of this research was to evaluate the extent of mechanical degradation on TiO2 nanotubes on Ti with and without nano-particulate silver coating using two different lengths of TiO2 nanotubes-300nm and ~1µm, which were fabricated on commercially pure Titanium (cp-Ti) rods using anodization method using two different electrolytic mediums-(1) deionized (DI) water with 1% HF, and (2) ethylene glycol with 1% HF, 0.5wt% NH4F and 10% DI water. Nanotubes fabricated rods were implanted into equine cadaver bone to evaluate mechanical damage at the surface. Silver was electrochemically deposited on these nanotubes and using a release study, silver ion concentrations were measured before and after implantation, followed by surface characterization using a Field Emission Scanning Electron Microscope (FESEM). In vitro cell-material interaction study was performed using human fetal osteoblast cells (hFOB) to understand the effect of silver coating using an MTT assay for proliferation and to determine any cytotoxic effect on the cells and to study its biocompatibility. No significant damage due to implantation was observed for nanotubes up to ~1µm length under current experimental conditions. Cell-materials interaction showed no cytotoxic effects on the cells due to silver coating and anodization of samples.

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Title: Mechanical degradation of TiO2 nanotubes with and without nanoparticulate silver coating
Creators: Anish Shivaram - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Susmita Bose - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA
Amit Bandyopadhyay - W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164-2920, USA. Electronic address: amitband@wsu.edu
Publication Details: Journal of the mechanical behavior of biomedical materials, Vol.59, pp.508-518
Academic Unit: Mechanical and Materials Engineering, School of
Publisher: Netherlands
Grant note: R01 AR067306 / NIAMS NIH HHS
Identifiers: 99900546908101842
Language: English
Resource Type: Journal article