Journal article
Mechanisms for Acute Stress-Induced Enhancement of Glutamatergic Transmission and Working Memory
Molecular psychiatry, Vol.16(2), pp.156-170
02/2011
Handle:
https://hdl.handle.net/2376/111586
PMCID: PMC3108461
PMID: 20458323
Abstract
Corticosteroid stress hormones have a strong impact on the function of prefrontal cortex (PFC), a central region controlling cognition and emotion, though the underlying mechanisms are elusive. We found that behavioral stressor or short-term corticosterone treatment
in vitro
induces a delayed and sustained potentiation of the synaptic response and surface expression of NMDARs and AMPARs in PFC pyramidal neurons via a mechanism depending on the induction of serum- and glucocorticoid-inducible kinase (SGK) and the activation of Rab4, which mediates receptor recycling between early endosomes and the plasma membrane. Working memory, a key function relying on glutamatergic transmission in PFC, is enhanced in acutely stressed animals via a SGK-dependent mechanism. These results suggest that acute stress, by activating glucocorticoid receptors (GRs), increases the trafficking and function of NMDARs and AMPARs via SGK/Rab4 signaling, which leads to the potentiated synaptic transmission, thereby facilitating cognitive processes mediated by the PFC.
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Details
- Title
- Mechanisms for Acute Stress-Induced Enhancement of Glutamatergic Transmission and Working Memory
- Creators
- Eunice Y Yuen - Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214Wenhua Liu - Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214Ilia N Karatsoreos - Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065Yong Ren - Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214Jian Feng - Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214Bruce S McEwen - Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065Zhen Yan - Department of Physiology and Biophysics, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, NY 14214
- Publication Details
- Molecular psychiatry, Vol.16(2), pp.156-170
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Grant note
- R01 MH085774-01A2 || MH / National Institute of Mental Health : NIMH R01 MH085774-02 || MH / National Institute of Mental Health : NIMH
- Identifiers
- 99900547566201842
- Language
- English
- Resource Type
- Journal article