Journal article
Mechanisms of Francisella tularensis Intracellular Pathogenesis
Cold Spring Harbor perspectives in medicine, Vol.3(4), pp.a010314-a010314
04/2013
Handle:
https://hdl.handle.net/2376/114769
PMCID: PMC3683997
PMID: 23545572
Abstract
Francisella tularensis
is a zoonotic intracellular pathogen and the causative agent of the debilitating febrile illness tularemia. Although natural infections by
F. tularensis
are sporadic and generally localized, the low infectious dose, with the ability to be transmitted to humans via multiple routes and the potential to cause life-threatening infections, has led to concerns that this bacterium could be used as an agent of bioterror and released intentionally into the environment. Recent studies of
F. tularensis
and other closely related
Francisella
species have greatly increased our understanding of mechanisms used by this organism to infect and cause disease within the host. Here, we review the intracellular life cycle of
Francisella
and highlight key genetic determinants and/or pathways that contribute to the survival and proliferation of this bacterium within host cells.
The bacterium
Francisella tularensis
causes a potentially life-threatening illness. It can be transmitted to humans by multiple routes, and its ability to proliferate within host cells is essential for virulence.
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Details
- Title
- Mechanisms of Francisella tularensis Intracellular Pathogenesis
- Creators
- Jean Celli - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840Thomas C Zahrt - Department of Microbiology and Molecular Genetics, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, Wisconsin 53226
- Publication Details
- Cold Spring Harbor perspectives in medicine, Vol.3(4), pp.a010314-a010314
- Academic Unit
- Paul G. Allen School for Global Animal Health
- Publisher
- Cold Spring Harbor Laboratory Press
- Identifiers
- 99900547981301842
- Language
- English
- Resource Type
- Journal article