Mechanisms of sleep-dependent consolidation of cortical plasticity

Sara J Aton; Julie Seibt; Michelle Dumoulin; Sushil K Jha; Nicholas Steinmetz; Tammi Coleman; Nirinjini Naidoo; Marcos G Frank

doi:10.1016/j.neuron.2009.01.007

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Mechanisms of sleep-dependent consolidation of cortical plasticity

Journal article

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Mechanisms of sleep-dependent consolidation of cortical plasticity

Sara J Aton, Julie Seibt, Michelle Dumoulin, Sushil K Jha, Nicholas Steinmetz, Tammi Coleman, Nirinjini Naidoo and Marcos G Frank

Neuron (Cambridge, Mass.), Vol.61(3), pp.454-466

02/12/2009

DOI: https://doi.org/10.1016/j.neuron.2009.01.007

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https://hdl.handle.net/2376/101570

PMCID: PMC2665998

PMID: 19217381

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https://doi.org/10.1016/j.neuron.2009.01.007View

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Abstract

NREM

LTP

CBI

cAMP

NDE

CREB

NBI

ODP

EMG

EEG

PKA

AMPAR

CaMKII

GluR1

Rp-8-Cl-cAMPS

VEH

NMDAR

REM

AVP

LTD

ERI

ERK

Sleep is thought to consolidate changes in synaptic strength, but the underlying mechanisms are unknown. We investigated the cellular events involved in this process in ocular dominance plasticity (ODP) - a canonical form of in vivo cortical plasticity triggered by monocular deprivation (MD) and consolidated by sleep via undetermined, activity-dependent mechanisms. We find that sleep consolidates ODP primarily by strengthening cortical responses to non-deprived eye stimulation. Consolidation is inhibited by reversible, intracortical antagonism of NMDA receptors (NMDARs) or cAMP-dependent protein kinase (PKA) during post-MD sleep. Consolidation is also associated with sleep-dependent increases in the activity of remodeling neurons, and in the phosphorylation of proteins required for potentiation of glutamatergic synapses. These findings demonstrate that synaptic strengthening via NMDAR and PKA activity is a key step in sleep-dependent consolidation of ODP.

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Title: Mechanisms of sleep-dependent consolidation of cortical plasticity
Creators: Sara J Aton - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA
Julie Seibt - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA
Michelle Dumoulin - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA
Sushil K Jha - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA
Nicholas Steinmetz - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA
Tammi Coleman - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA
Nirinjini Naidoo - Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, PA
Marcos G Frank - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA
Publication Details: Neuron (Cambridge, Mass.), Vol.61(3), pp.454-466
Academic Unit: Biomedical Sciences, Department of
Identifiers: 99900546559201842
Language: English
Resource Type: Journal article