Journal article
Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors
European journal of pharmacology, Vol.175(1), pp.97-100
1990
Handle:
https://hdl.handle.net/2376/107756
PMID: 2157601
Abstract
Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal construction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with β-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal κ-opioid receptors.
Metrics
9 Record Views
Details
- Title
- Mediation of nitrous oxide analgesia in mice by spinal and supraspinal κ-opioid receptors
- Creators
- R.M Quock - Departments of Basic Sciences, USAJ.A Best - Pediatric Dentistry, Marquette University School of Dentistry, Milwaukee, WI 53233, U.S.AD.C Chen - Department of Medicinal Chemistry, College of Pharmacy, USAL.K Vaughn - Pediatric Dentistry, Marquette University School of Dentistry, Milwaukee, WI 53233, U.S.AP.S Portoghese - Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, MN 55455, U.S.AA.E Takemori - Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, MN 55455, U.S.A
- Publication Details
- European journal of pharmacology, Vol.175(1), pp.97-100
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900546962201842
- Language
- English
- Resource Type
- Journal article