Journal article
Meiosis and sex chromosome aneuploidy: how meiotic errors cause aneuploidy; how aneuploidy causes meiotic errors
Current opinion in genetics & development, Vol.16(3), pp.323-329
2006
Handle:
https://hdl.handle.net/2376/105124
PMID: 16647844
Abstract
As a group, sex chromosome aneuploidies — the 47,XXY, 47,XYY, 47,XXX and 45,X conditions — constitute the most common class of chromosome abnormality in human live-births. Considerable attention has been given to the somatic abnormalities associated with these conditions, but less is known about their meiotic phenotypes; that is, how does sex chromosome imbalance influence the meiotic process. This has become more important with the advent of assisted reproductive technologies, because individuals previously thought to be infertile can now become biological parents. Indeed, there are several recent reports of successful pregnancies involving 47,XXY fathers, and suggestions that cryopreservation of ovarian tissue might impart fertility to at least some Turner syndrome individuals. Thus, the possible consequences of sex chromosome aneuploidy on meiotic chromosome segregation need to be explored.
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Details
- Title
- Meiosis and sex chromosome aneuploidy: how meiotic errors cause aneuploidy; how aneuploidy causes meiotic errors
- Creators
- Heather HallPatricia HuntTerry Hassold
- Publication Details
- Current opinion in genetics & development, Vol.16(3), pp.323-329
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546900301842
- Language
- English
- Resource Type
- Journal article