Journal article
Meiotic failure in male mice lacking an X-linked factor
Genes & development, Vol.22(5), pp.682-691
03/01/2008
Handle:
https://hdl.handle.net/2376/115707
PMCID: PMC2259036
PMID: 18316482
Abstract
Meiotic silencing of sex chromosomes may cause their depletion of meiosis-specific genes during evolution. Here, we challenge this hypothesis by reporting the identification of TEX11 as the first X-encoded meiosis-specific factor in mice. TEX11 forms discrete foci on synapsed regions of meiotic chromosomes and appears to be a novel constituent of meiotic nodules involved in recombination. Loss of TEX11 function causes chromosomal asynapsis and reduced crossover formation, leading to elimination of spermatocytes, respectively, at the pachytene and anaphase I stages. Specifically, TEX11-deficient spermatocytes with asynapsed autosomes undergo apoptosis at the pachytene stage, while those with only asynapsed sex chromosomes progress. However, cells that survive the pachytene stage display chromosome nondisjunction at the first meiotic division, resulting in cell death and male infertility. TEX11 interacts with SYCP2, which is an integral component of the synaptonemal complex lateral elements. Thus, TEX11 promotes initiation and/or maintenance of synapsis and formation of crossovers, and may provide a physical link between these two meiotic processes.
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Details
- Title
- Meiotic failure in male mice lacking an X-linked factor
- Creators
- Fang Yang - Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USAKatarina Gell - Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, SwedenGodfried W van der Heijden - Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USASigrid Eckardt - Center for Animal Transgenesis and Germ Cell Research, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USAN. Adrian Leu - Center for Animal Transgenesis and Germ Cell Research, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USADavid C Page - Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USARicardo Benavente - Department of Cell and Developmental Biology, Biocenter of the University of Würzburg, Am Hubland, Würzburg 97074, GermanyChengtao Her - School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USAChrister Höög - Department of Cell and Molecular Biology, Karolinska Institutet, SE-171 77 Stockholm, SwedenK. John McLaughlin - Center for Animal Transgenesis and Germ Cell Research, New Bolton Center, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USAPeijing Jeremy Wang - Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
- Publication Details
- Genes & development, Vol.22(5), pp.682-691
- Academic Unit
- Molecular Biosciences, School of
- Publisher
- Cold Spring Harbor Laboratory Press
- Identifiers
- 99900547552501842
- Language
- English
- Resource Type
- Journal article