Journal article
Mesoporous Carbon Nanospheres with ZnO Nanolids for Multimodal Therapy of Lung Cancer
ACS applied bio materials, Vol.1(4), pp.1165-1173
10/15/2018
PMID: 34996157
Abstract
To improve therapeutic efficacy, we designed novel poly(ethylene glycol) (PEG)-modified oxidized mesoporous carbon nanospheres (OMCNPs) that were loaded with the therapeutic drug doxorubicin (DOX) and targeted with ligand hyaluronic acid (HA) to kill lung cancer cells. ZnO quantum dots (ZnO QDs) were introduced not only to cap OMCNP-based carriers but also to chelate with DOX, which exhibited a high drug-loading capacity. Upon cellular uptake, the pH-sensitive ZnO lids dissolved to Zn2+ in tumor cells, resulting in dissociation of the Zn2+-DOX complex and controlled release of DOX. Moreover, the novel OMCNP-based system could generate hyperthermia and facilitate the release of loaded DOX with near-infrared (NIR) irradiation. The combined chemo-/photothermal-targeted therapy exhibited significant advantages superior to single chemotherapy or photothermal therapy. This technology provided an excellent lung cancer cell-targeted drug delivery system, integrating chemotherapy with photothermal therapy. This chemo-/photothermal therapy effectively improved the therapeutic efficacy with lower adverse effects to normal tissues.
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Details
- Title
- Mesoporous Carbon Nanospheres with ZnO Nanolids for Multimodal Therapy of Lung Cancer
- Creators
- Xiaoli Cai - Central China Normal UniversityHongye Yan - Central China Normal UniversityYanan Luo - Central China Normal UniversityYang Song - Washington State UniversityYuting Zhao - Washington State UniversityHe Li - Washington State UniversityDan Du - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- ACS applied bio materials, Vol.1(4), pp.1165-1173
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Amer Chemical Soc
- Number of pages
- 9
- Grant note
- 21575047 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 201706770044 / China Scholarship Council
- Identifiers
- 99901227637001842
- Language
- English
- Resource Type
- Journal article