Journal article
Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer
Nano research, Vol.13(6), pp.1739-1748
06/01/2020
Abstract
The synergistic therapy of chemotherapy and photothermal therapy (PTT) has been reported as a promising antitumor strategy. To achieve effective combination therapy, developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary. Herein, a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin (DOX) loading. We further designed PtPd-ethylene glycol (PEG)-folic acid (FA)-doxorubicin (DOX) nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting. Moreover, excellent photoacoustic (PA) imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles' targeting effect. The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.
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Details
- Title
- Mesoporous PtPd nanoparticles for ligand-mediated and imaging-guided chemo-photothermal therapy of breast cancer
- Creators
- Yanpeng Jia - State Key Laboratory of BiotherapyYang Song - Washington State UniversityYing Qu - State Key Laboratory of BiotherapyJinrong Peng - State Key Laboratory of BiotherapyKun Shi - State Key Laboratory of BiotherapyDan Du - Washington State UniversityHe Li - Chengdu University of Information TechnologyYuehe Lin - Washington State UniversityZhiyong Qian - State Key Laboratory of Biotherapy
- Publication Details
- Nano research, Vol.13(6), pp.1739-1748
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Tsinghua Univ Press
- Number of pages
- 10
- Grant note
- 2018M631094 / China Postdoctoral Science Foundation 31930067; 31525009; 31800797; 31771096 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) 2017YFC1103502; 2016YFA0201402 / National Key Research and Development Program of China; National Key Research & Development Program of China BX20180207 / Postdoctoral Innovation Talents Support Program ZYGD18002 / 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University
- Identifiers
- 99901227636301842
- Language
- English
- Resource Type
- Journal article