Journal article
Metoclopramide potentiates d-amphetamine-induced hypermotility and stereotypy in rat
Pharmacology, biochemistry and behavior, Vol.27(1), pp.165-169
1987
Handle:
https://hdl.handle.net/2376/102024
PMID: 3615538
Abstract
The substituted benzamide metoclopramide has been reported to block the behavioral effects of dopamine agonists, whereas its congener sulpiride potentiates these effects. We injected metoclopramide 2.0, 4.0, or 8.0 mg/kg PO into rats 2 hr before d-amphetamine 1.5 mg/kg IP and measured locomotion for 3 hr. We injected metoclopramide 8.0 mg/kg PO into rats 2 hr before d-amphetamine 1.5, 3.0, or 6.0 mg/kg IP and measured stereotypy for 3 hr. Metoclopramide potentiated the effects of all doses of d-amphetamine on both measures; peak effects occurred in the second or third hr after d-amphetamine injection. Metoclopramide alone tended to reduce behavior. The results suggest that metoclopramide is qualitatively similar to sulpiride in its interaction with d-amphetamine, and that metoclopramide's mechanism of action is not a simple dopaminergic antagonism. Clinicians are advised that metoclopramide, which is prescribed extensively for gastrointestinal and other disorders, may interact adversely with drugs that affect dopaminergic function.
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Details
- Title
- Metoclopramide potentiates d-amphetamine-induced hypermotility and stereotypy in rat
- Creators
- James L HowardGerald T PollardRebecca M CraftKenneth W Rohrbach
- Publication Details
- Pharmacology, biochemistry and behavior, Vol.27(1), pp.165-169
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900546787101842
- Language
- English
- Resource Type
- Journal article