Journal article
Microinfusion of aminopeptidase M into the paraventricular nucleus of the hypothalamus in normotensive and hypertensive rats
Brain research bulletin, Vol.39(4), pp.235-240
1996
Handle:
https://hdl.handle.net/2376/109229
PMID: 8963689
Abstract
Normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) received aminopeptidase M (AmM) delivered into the paraventricular nucleus of the hypothalamus (PVN). Resulting changes in blood pressure were recorded in both anesthetized and alert animals. The findings indicate significant dose-determined decreases in blood pressure in members of both strains with SHR more responsive than WKY rats. The respective drops in blood pressure for members within each strain were equivalent for the anesthetized and alert conditions. Pretreatment with the specific angiotensin receptor antagonist, sarthran, [Sar
1, Thr
8]Anll, into the PVN greatly diminished these responses, suggesting the involvement of the brain angiotensin system. Additionally, a sympathetic nervous system blocker, hexamethonium, and the arginine vasopressin antagonist, Pmp
1, OMeTyr
2[Arg]vasopressin, were peripherally administered to assess the potential contributions of these systems to cardiovascular regulation by the brain angiotensin system. The use of these blockers, individually and combined, attenuated responsiveness to infusion of AmM into the PVN. We conclude that AmM can act as a hypotensive agent in both SHR and WKY rats, and that this decrease in blood pressure is at least partially mediated via the brain angiotensin system although other systems may play a role.
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Details
- Title
- Microinfusion of aminopeptidase M into the paraventricular nucleus of the hypothalamus in normotensive and hypertensive rats
- Creators
- Carol M Batt - Department of Social and Behavioral Sciences, Sacred Heart University, 5151 Park Avenue, Fairfield, CT 06432-1000, USALaurie L Jensen - Department of Psychology, Washington State University, Pullman, WA 99164-4820, USAJoseph W Harding - Department of Psychology, Washington State University, Pullman, WA 99164-4820, USAJohn W Wright - Department of Psychology, Washington State University, Pullman, WA 99164-4820, USA
- Publication Details
- Brain research bulletin, Vol.39(4), pp.235-240
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547003201842
- Language
- English
- Resource Type
- Journal article