Journal article
Microinjection of interleukin-1 into brain: Separation of sleep and fever responses
Physiology & behavior, Vol.45(1), pp.169-176
1989
Handle:
https://hdl.handle.net/2376/118242
PMID: 2786222
Abstract
Interleukin-1 (IL1) and muramyl peptides are somnogenic, pyrogenic, immune response modifiers, Their central nervous system loci of action with respect to sleep and body temperature in rabbits were examined in this study using microinjection techniques. Unilateral microinjection of IL1 into various basal forebrain or brain stem sites resulted in elevated colonic temperatures (T
c), but the duration of slow-wave sleep (SWS) was unchanged compared to results obtained after control injections. Injection of IL1 into posterior hypothalamic areas failed to elicit either sleep or temperature responses. In contrast to these results, injection of either IL1 or muramyl dipeptide into the Aqueduct of Sylvius was followed by enhanced SWS and T
c. These results show that IL1-induced sleep and fever responses can be separated. Somnogenic sites of action for IL1 and muramyl peptides remain unknown.
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Details
- Title
- Microinjection of interleukin-1 into brain: Separation of sleep and fever responses
- Creators
- James S Walter - Hines VA Hospital, Rehabilitation R & D Center (151L), Hines, IL 60141 USAPaul Meyers - Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208 USAJames M Krueger - Department of Physiology and Biophysics, University of Tennessee, Memphis, Memphis, TN 38163 USA
- Publication Details
- Physiology & behavior, Vol.45(1), pp.169-176
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547861501842
- Language
- English
- Resource Type
- Journal article