Journal article
Microwave-processed nanocrystalline hydroxyapatite: Simultaneous enhancement of mechanical and biological properties
Acta biomaterialia, Vol.6(9), pp.3782-3790
2010
Handle:
https://hdl.handle.net/2376/101910
PMCID: PMC2910217
PMID: 20230922
Abstract
Despite the excellent bioactivity of hydroxyapatite (HA) ceramics, poor mechanical strength has limited the applications of these materials primarily to coatings and other non-load-bearing areas as bone grafts. Using synthesized HA nanopowder, dense compacts with grain sizes in the nanometer to micrometer range were processed via microwave sintering between 1000 and 1150
°C for 20
min. Here we demonstrate that the mechanical properties, such as compressive strength, hardness and indentation fracture toughness, of HA compacts increased with a decrease in grain size. HA with 168
±
86
nm grain size showed the highest compressive strength of 395
±
42
MPa, hardness of 8.4
±
0.4
GPa and indentation fracture toughness of 1.9
±
0.2
MPa
m
1/2. To study the
in vitro biological properties, HA compacts with grain size between 168
nm and 1.16
μm were assessed for
in vitro bone cell–material interactions with human osteoblast cell line. Vinculin protein expression for cell attachment and bone cell proliferation using MTT assay showed that surfaces with finer grains provided better bone cell–material interactions than coarse-grained samples. Our results indicate simultaneous improvements in mechanical and biological properties in microwave sintered HA compacts with nanoscale grain size.
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Details
- Title
- Microwave-processed nanocrystalline hydroxyapatite: Simultaneous enhancement of mechanical and biological properties
- Creators
- Susmita BoseSudip DasguptaSolaiman TarafderAmit Bandyopadhyay
- Publication Details
- Acta biomaterialia, Vol.6(9), pp.3782-3790
- Academic Unit
- Mechanical and Materials Engineering, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546633001842
- Language
- English
- Resource Type
- Journal article