Journal article
Mitochondrial-targeted multifunctional mesoporous Au@Pt nanoparticles for dual-mode photodynamic and photothermal therapy of cancers
Nanoscale, Vol.9(41), pp.15813-15824
10/26/2017
PMID: 29018855
Abstract
In the conventional non-invasive cancer treatments, such as photodynamic therapy (PDT) and photothermal therapy (PTT), light irradiation is precisely focused on tumors to induce apoptosis via the generation of reactive oxygen species (ROS) or localized heating. However, overconsumption of oxygen and restricted diffusion distance of ROS limit the therapeutic effects on hypoxic tumors. Herein, we developed a platform for the rapid uptake of multifunctionalized Au@Pt nanoparticles (NPs) by mitochondria in cancer cells. The mesoporous Au@Pt nanoparticles were labeled with a cell-targeting ligand (folic acid), a mitochondria-targeting group (triphenylphosphine (TPP)), and a photosensitizer (Ce6). This led to significant improvement of the PDT efficacy due to an enhanced cellular uptake, an effective mitochondrial ROS burst, and a rapid intelligent release of oxygen. Moreover, Au@Pt NPs can convert laser radiation into heat, resulting in thermally induced cell damage. This nanosystem could be used as a dual-mode phototherapeutic agent for enhanced cancer therapy and molecular targets associated with disease progression. We achieved a mitochondria-targeted multifunctional therapy strategy (a combination of PDT and PTT) to substantially improve the therapeutic efficiency.
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Details
- Title
- Mitochondrial-targeted multifunctional mesoporous Au@Pt nanoparticles for dual-mode photodynamic and photothermal therapy of cancers
- Creators
- Yang Song - Washington State UniversityQiurong Shi - Washington State UniversityChengzhou Zhu - Washington State UniversityYanan Luo - Washington State UniversityQian Lu - Washington State UniversityHe Li - Washington State UniversityRanfeng Ye - Washington State UniversityDan Du - Washington State UniversityYuehe Lin - Washington State University
- Publication Details
- Nanoscale, Vol.9(41), pp.15813-15824
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Royal Soc Chemistry
- Number of pages
- 12
- Grant note
- 21575047 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) Washington State University
- Identifiers
- 99901227635501842
- Language
- English
- Resource Type
- Journal article