Journal article
MnO2 Nanotubes-based NanoSearchlight for Imaging of Multiple MicroRNAs in Live Cells
ACS applied materials & interfaces, Vol.9(28), pp.23325-23332
07/03/2017
PMID: 28493665
Abstract
Sensitive assay and imaging of multiple low-abundance microRNAs (miRNAs) in living cells remain a grand challenge. Herein, based on polyelectrolyte induced reduction, a facile approach has been proposed to synthesize novel MnO
2
nanotubes. Owing to the remarkably strong fluorescence quenching ability, low cytotoxicity and excellent colloid stability, the as-prepared MnO
2
nanotubes showed great potential for simultaneous detection and imaging of multiple miRNAs
in vitro
and
in situ
in living cells for the first time. Besides, MnO
2
nanotubes can be reduced to Mn
2+
by intracellular acid pH or glutathione, which may serve as activatable contrast reagent for MRI. Therefore, the MnO
2
nanotubes based probes, termed “NanoSearchlight”, provide a promising, multimodal imaging tool for precise and accurate diagnosis and prognosis of cancers.
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Details
- Title
- MnO2 Nanotubes-based NanoSearchlight for Imaging of Multiple MicroRNAs in Live Cells
- Creators
- Qian Lu - Washington State UniversityDaniel Ericson - University at Buffalo, State University of New YorkYang Song - Washington State UniversityChengzhou Zhu - Washington State UniversityRanfeng Ye - Washington State UniversitySongqin Liu - Southeast UniversityJoseph A. Spernyak - Roswell Park Comprehensive Cancer CenterDan Du - Washington State UniversityHe Li - Washington State UniversityYun Wu - University at Buffalo, State University of New YorkYuehe Lin - Washington State University
- Publication Details
- ACS applied materials & interfaces, Vol.9(28), pp.23325-23332
- Academic Unit
- School of Mechanical and Materials Engineering
- Identifiers
- 99901227841401842
- Language
- English
- Resource Type
- Journal article