Journal article
Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish
Frontiers in endocrinology (Lausanne), Vol.8, pp.9-9
01/26/2017
Handle:
https://hdl.handle.net/2376/106404
PMCID: PMC5266698
PMID: 28184214
Abstract
Glucose homeostasis is an important element of energy balance and is conserved in organisms from fruit fly to mammals. Central to the control of circulating glucose levels in vertebrates are the endocrine cells of the pancreas, particularly the insulin-producing β-cells and the glucagon producing α-cells. A feature of α- and β-cells is their plasticity, an ability to adapt, in function and number as a response to physiological and pathophysiological conditions of increased hormone demand. The molecular mechanisms underlying these adaptive responses that maintain glucose homeostasis are incompletely defined. The zebrafish is an attractive model due to the low cost, high fecundity, and amenability to genetic and compound screens, and mechanisms governing the development of the pancreatic endocrine cells are conserved between zebrafish and mammals. Post development, both β- and α-cells of zebrafish display plasticity as in mammals. Here, we summarize the studies of pancreatic endocrine cell adaptation in zebrafish. We further explore the utility of the zebrafish as a model for diabetes, a relevant topic considering the increase in diabetes in the human population.
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Details
- Title
- Modeling Pancreatic Endocrine Cell Adaptation and Diabetes in the Zebrafish
- Creators
- Lisette A Maddison - Department of Molecular Physiology and Biophysics, Vanderbilt University School of MedicineWenbiao Chen - Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine
- Publication Details
- Frontiers in endocrinology (Lausanne), Vol.8, pp.9-9
- Academic Unit
- Center for Reproductive Biology
- Publisher
- Frontiers Media S.A
- Grant note
- DK088686 / National Institutes of Health 1-13-BS-027 / American Diabetes Association
- Identifiers
- 99900546648301842
- Language
- English
- Resource Type
- Journal article