Moderate high fat diet increases sucrose self-administration in young rats

Dianne P Figlewicz; Jennifer L Jay; Molly A Acheson; Irwin J Magrisso; Constance H West; Aryana Zavosh; Stephen C Benoit; Jon F Davis

doi:10.1016/j.appet.2012.09.021

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Moderate high fat diet increases sucrose self-administration in young rats

Journal article

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Peer reviewed

Moderate high fat diet increases sucrose self-administration in young rats

Dianne P Figlewicz, Jennifer L Jay, Molly A Acheson, Irwin J Magrisso, Constance H West, Aryana Zavosh, Stephen C Benoit and Jon F Davis

Appetite, Vol.61(1), pp.19-29

02/2013

DOI: https://doi.org/10.1016/j.appet.2012.09.021

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https://hdl.handle.net/2376/104148

PMCID: PMC3538965

PMID: 23023044

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https://doi.org/10.1016/j.appet.2012.09.021View

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Abstract

Body Composition

Immunohistochemistry

Sucrose - administration & dosage

Glucose Tolerance Test

Fasting

Nucleus Accumbens - metabolism

RNA, Messenger - genetics

Rats

Male

Chromatography, High Pressure Liquid

RNA, Messenger - metabolism

Agouti-Related Protein - metabolism

Motivation - drug effects

Animals

Hypothalamus - metabolism

Agouti-Related Protein - genetics

Diet, High-Fat

Dietary Fats - administration & dosage

Hypothalamus - drug effects

Nucleus Accumbens - drug effects

We have previously reported that a moderately high fat diet increases motivation for sucrose in adult rats. In this study, we tested the motivational, neurochemical, and metabolic effects of the high fat diet in male rats transitioning through puberty, during 5-8 weeks of age. We observed that the high fat diet increased motivated responding for sucrose, which was independent of either metabolic changes or changes in catecholamine neurotransmitter metabolites in the nucleus accumbens. However, AGRP mRNA levels in the hypothalamus were significantly elevated. We demonstrated that increased activation of AGRP neurons is associated with motivated behavior, and that exogenous (third cerebroventricular) AGRP administration resulted in significantly increased motivation for sucrose. These observations suggest that increased expression and activity of AGRP in the medial hypothalamus may underlie the increased responding for sucrose caused by the high fat diet intervention. Finally, we compared motivation for sucrose in pubertal vs. adult rats and observed increased motivation for sucrose in the pubertal rats, which is consistent with previous reports that young animals and humans have an increased preference for sweet taste, compared with adults. Together, our studies suggest that background diet plays a strong modulatory role in motivation for sweet taste in adolescent animals.

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Title: Moderate high fat diet increases sucrose self-administration in young rats
Creators: Dianne P Figlewicz - Metabolism/Endocrinology, VA Puget Sound Health Care System 151, 1660 So Columbian Way, Seattle, WA 98108, USA. latte@u.washington.edu
Jennifer L Jay
Molly A Acheson
Irwin J Magrisso
Constance H West
Aryana Zavosh
Stephen C Benoit
Jon F Davis
Publication Details: Appetite, Vol.61(1), pp.19-29
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: England
Grant note: R01 DK066223 / NIDDK NIH HHS R01 DK040963 / NIDDK NIH HHS P30 DK017047 / NIDDK NIH HHS DK40963 / NIDDK NIH HHS NIH DK066223 / NIDDK NIH HHS
Identifiers: 99900546821101842
Language: English
Resource Type: Journal article