Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies

Timothy STRASSMAIER; Ramalinga UMA; Ambarish S GHATPANDE; Tapasree BANDYOPADHYAY; Michelle SCHAFFER; John WITTE; Patrick G MCDOUGAL; R. Lane BROWN; Jeffrey W KARPEN

doi:10.1021/jm0502485

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Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies

Journal article

Open access

Peer reviewed

Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies

Timothy STRASSMAIER, Ramalinga UMA, Ambarish S GHATPANDE, Tapasree BANDYOPADHYAY, Michelle SCHAFFER, John WITTE, Patrick G MCDOUGAL, R. Lane BROWN and Jeffrey W KARPEN

Journal of medicinal chemistry, Vol.48(18), pp.5805-5812

2005

DOI: https://doi.org/10.1021/jm0502485

Handle:

https://hdl.handle.net/2376/110623

PMCID: PMC2467444

PMID: 16134947

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Abstract

Fundamental and applied biological sciences. Psychology

Miscellaneous

Cell membranes. Ionic channels. Membrane pores

Pharmacology. Drug treatments

Biological and medical sciences

Molecular and cellular biology

Medical sciences

Cell structures and functions

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Title: Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies
Creators: Timothy STRASSMAIER - Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, United States
Ramalinga UMA - Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, United States
Ambarish S GHATPANDE - Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, Colorado 80262, United States
Tapasree BANDYOPADHYAY - Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, United States
Michelle SCHAFFER - Department of Chemistry, Reed College, Portland, Oregon 97202, United States
John WITTE - Department of Chemistry, Reed College, Portland, Oregon 97202, United States
Patrick G MCDOUGAL - Department of Chemistry, Reed College, Portland, Oregon 97202, United States
R. Lane BROWN - Neurological Sciences Institute, Oregon Health & Science University, Portland, Oregon 97239, United States
Jeffrey W KARPEN - Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, Oregon 97239, United States
Publication Details: Journal of medicinal chemistry, Vol.48(18), pp.5805-5812
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: American Chemical Society; Washington, DC
Identifiers: 99900547375701842
Language: English
Resource Type: Journal article