Journal article
Modular Nucleic Acid Surrogates. Solid Phase Synthesis of α-Helical Peptide Nucleic Acids (αPNAs)
Organic letters, Vol.1(3), pp.403-406
08/12/1999
Handle:
https://hdl.handle.net/2376/105944
PMID: 10822581
Abstract
The synthesis and characterization of prototype α-helical peptide nucleic acid (αPNA) modules 1−3 as well as disulfide dimers 4 and 5 are reported. These molecules combine an α-helical peptidyl scaffold with well-defined nucleobase molecular recognition patterns and could serve as a basis for novel antisense and/or antigene agents. Structure assignments for these αPNAs were supported by MALDI-TOF mass spectrometry, and the α-helical nature of 4 in water was confirmed by circular dichroism (CD) spectroscopy.
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Details
- Title
- Modular Nucleic Acid Surrogates. Solid Phase Synthesis of α-Helical Peptide Nucleic Acids (αPNAs)
- Creators
- Philip GarnerSubhakar DeyYumei HuangXiao Zhang
- Publication Details
- Organic letters, Vol.1(3), pp.403-406
- Academic Unit
- Chemistry, Department of; Chemical Engineering and Bioengineering, School of
- Publisher
- American Chemical Society
- Identifiers
- 99900546967801842
- Language
- English
- Resource Type
- Journal article