Journal article
Modulation of Bovine Leukemia Virus-Associated Spontaneous Lymphocyte Proliferation by Monoclonal Antibodies to Lymphocyte Surface Molecules
Clinical immunology and immunopathology, Vol.83(2), pp.156-164
05/1997
Handle:
https://hdl.handle.net/2376/117634
PMID: 9143376
Abstract
Both human T lymphotropic virus (HTLV) and bovine leukemia virus (BLV) infections are characterized byin vitroproliferation of peripheral blood lymphocytes in the absence of exogenous antigens or mitogens. Differential expression of lymphocyte surface molecules in HTLV and BLV infection suggests that lymphocyte dysregulation may involve signaling through surface molecules involved in immune regulation. We examined the expression of adhesion and major histocompatibility (MHC) molecules on circulating lymphocytes from BLV-infected cows with persistent lymphocytosis and the ability of monoclonal antibodies to these molecules to modulate spontaneous lymphocyte proliferation. The integrin molecule, CD11c, and both MHC class I and MHC class II molecules were upregulated on B and T lymphocytes from PL cows. Anti-CD11c antibody was stimulatory to lymphocyte proliferation regardless of BLV status and had a greater stimulatory effect on spontaneously proliferating lymphocytes from persistently lymphocytotic cows than on normal bovine lymphocytes. Antibodies to bovine class I and class II inhibited spontaneous lymphocyte proliferation. Results suggest that lymphocyte dysregulation in BLV-induced persistent lymphocytosis involves upregulation of and signaling through lymphocyte surface molecules which are involved in immune activation of lymphocytes.
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Details
- Title
- Modulation of Bovine Leukemia Virus-Associated Spontaneous Lymphocyte Proliferation by Monoclonal Antibodies to Lymphocyte Surface Molecules
- Creators
- Diana M StoneLinda K NortonWilliam C Davis
- Publication Details
- Clinical immunology and immunopathology, Vol.83(2), pp.156-164
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900548584101842
- Language
- English
- Resource Type
- Journal article