Journal article
Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen
Immunogenetics (New York), Vol.54(3), pp.216-220
06/2002
Handle:
https://hdl.handle.net/2376/113795
PMID: 12073152
Abstract
In this report, we describe the cloning, sequencing, and expression of the bovine orthologue of CD26 (BoCD26). Several monoclonal antibodies specific for a molecule, activation molecule 3 (ACT3), aberrantly expressed on superantigen-stimulated bovine CD8(+) lymphocytes, reacted with recombinant BoCD26 expressed in COS-7 and CHO cells. We also showed that human CD8(+) T cells stimulated by a superantigen expressed CD26 at high levels. These results demonstrate that ACT3 is identical to BoCD26 and suggest that CD26 upregulation on CD8(+) T cells is a general phenomenon of superantigens and not limited to their effects on bovine cells.
Metrics
7 Record Views
Details
- Title
- Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen
- Creators
- Sang-Un Lee - Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 83844, USAYong-Ho ParkWilliam C DavisJo HamiltonJan NaessensGregory A Bohach
- Publication Details
- Immunogenetics (New York), Vol.54(3), pp.216-220
- Academic Unit
- Veterinary Microbiology and Pathology, Department of
- Publisher
- United States
- Grant note
- AI2841 / NIAID NIH HHS P20-RR15587 / NCRR NIH HHS
- Identifiers
- 99900548275401842
- Language
- English
- Resource Type
- Journal article