Journal article
Multi-alignment of orthologous genome regions in five species provides new insights into the evolutionary make-up of mammalian genomes
Chromosome research, Vol.13(7), pp.707-715
10/2005
Handle:
https://hdl.handle.net/2376/103935
PMID: 16235120
Abstract
Evidence has shown that bacterial genomes have undergone random shuffling of genomic elements consisting of one to two genes. In order to delineate such genome-shuffling events in mammals, we constructed a high-resolution map of Sus scrofa chromosome 3 (SSC3) with a total of 116 genes/markers. Alignment of this pig map to orthologous regions in human, dog, mouse and rat led to the identification of 31 provisional conserved ancestral blocks (CABs) in these five species. Among them, only 3 CABs (<10%) had one gene, indicating that one-gene shuffling is not frequent in mammals. The sizes of CABs vary significantly within a species, but each may be relatively consistent in different species with a scale to species-genome evolution. The type and frequency of rearrangement events that takes place, either intra- or interchromosomal, depends on the evolutionary regions and species under comparison. Characterization of 36 tentative breakpoint regions flanking these 31 CABs indicated that they occupied ∼43 Mb in length and featured genome deserts, gene duplications, and birth/death of species-specific genes in humans. Identification of CABs provides an alternative for further determination of the evolutionary make-up of mammalian genomes.
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Details
- Title
- Multi-alignment of orthologous genome regions in five species provides new insights into the evolutionary make-up of mammalian genomes
- Creators
- Zhihua Jiang - Department of Animal Sciences Washington State University Pullman WA 99164 USAJennifer Michal - Department of Animal Sciences Washington State University Pullman WA 99164 USAJenna Melville - Department of Molecular Biology and Genetics University of Guelph ON N1G 2W1 CanadaHeather Baltzer - Department of Molecular Biology and Genetics University of Guelph ON N1G 2W1 Canada
- Publication Details
- Chromosome research, Vol.13(7), pp.707-715
- Academic Unit
- Animal Sciences, Department of
- Publisher
- Kluwer Academic Publishers; Dordrecht
- Identifiers
- 99900546644601842
- Language
- English
- Resource Type
- Journal article