Journal article
Multiscale perspectives of virus entry via endocytosis
Virology journal, Vol.10(1), pp.177-177
2013
Handle:
https://hdl.handle.net/2376/105116
PMCID: PMC3679726
PMID: 23734580
Abstract
Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate infections. Understanding of virus entry via endocytosis is critically important for the design of antiviral strategies. Virus entry via endocytosis is a complex process involving hundreds of cellular proteins. The entire process is dictated by events occurring at multiple time and length scales. In this review, we discuss and evaluate the available means to investigate virus endocytic entry, from both experimental and theoretical/numerical modeling fronts, and highlight the importance of multiscale features. The complexity of the process requires investigations at a systems biology level, which involves the combination of different experimental approaches, the collaboration of experimentalists and theorists across different disciplines, and the development of novel multiscale models.
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Details
- Title
- Multiscale perspectives of virus entry via endocytosis
- Creators
- Eric Barrow - School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USAAnthony V Nicola - Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USAJin Liu - School of Mechanical and Materials Engineering, Washington State University, Pullman, WA 99164, USA
- Publication Details
- Virology journal, Vol.10(1), pp.177-177
- Academic Unit
- Veterinary Microbiology and Pathology, Department of; Mechanical and Materials Engineering, School of
- Publisher
- BioMed Central
- Identifiers
- 99900546896401842
- Language
- English
- Resource Type
- Journal article