Journal article
Myocardial AKT: The Omnipresent Nexus
Physiological reviews, Vol.91(3), pp.1023-1070
07/2011
Handle:
https://hdl.handle.net/2376/114793
PMCID: PMC3674828
PMID: 21742795
Abstract
One of the greatest examples of integrated signal transduction is revealed by examination of effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of multiple afferent and efferent signals, AKT exemplifies a molecular sensing node that coordinates dynamic responses of the cell in literally every aspect of biological responses. The balanced and nuanced nature of homeostatic signaling is particularly essential within the myocardial context, where regulation of survival, energy production, contractility, and response to pathological stress all flow through the nexus of AKT activation or repression. Equally important, the loss of regulated AKT activity is primarily the cause or consequence of pathological conditions leading to remodeling of the heart and eventual decompensation. This review presents an overview compendium of the complex world of myocardial AKT biology gleaned from more than a decade of research. Summarization of the widespread influence that AKT exerts upon myocardial responses leaves no doubt that the participation of AKT in molecular signaling will need to be reckoned with as a seemingly omnipresent regulator of myocardial molecular biological responses.
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Details
- Title
- Myocardial AKT: The Omnipresent Nexus
- Creators
- Mark A Sussman - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaMirko Völkers - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaKimberlee Fischer - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaBrandi Bailey - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaChristopher T Cottage - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaShabana Din - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaNatalie Gude - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaDaniele Avitabile - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaRoberto Alvarez - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaBalaji Sundararaman - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaPearl Quijada - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaMatt Mason - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaMathias H Konstandin - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaAmy Malhowski - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaZhaokang Cheng - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaMohsin Khan - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, CaliforniaMichael McGregor - Department of Biology, San Diego State University, SDSU Heart Institute, San Diego, California
- Publication Details
- Physiological reviews, Vol.91(3), pp.1023-1070
- Academic Unit
- Pharmaceutical Sciences, Department of
- Identifiers
- 99900547887701842
- Language
- English
- Resource Type
- Journal article