Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes

Allison B Coffin; Alain Dabdoub; Matthew W Kelley; Arthur N Popper

doi:10.1016/j.heares.2006.11.004

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Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes

Journal article

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Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes

Allison B Coffin, Alain Dabdoub, Matthew W Kelley and Arthur N Popper

Hearing research, Vol.224(1), pp.15-26

2007

DOI: https://doi.org/10.1016/j.heares.2006.11.004

Handle:

https://hdl.handle.net/2376/109948

PMCID: PMC1847575

PMID: 17204383

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Abstract

Teleost

Lagena

Hearing

Myosin

Hair cell

Saccule

Utricle

Unconventional myosins are critical motor proteins in the vertebrate inner ear. Mutations in any one of at least six different myosins can lead to human hereditary deafness, but the precise functions of these proteins in the ear are unknown. This study uses a comparative approach to better understand the role of myosins VI and VIIa in vertebrate ears by examining protein distribution for these two myosins in the ears of evolutionarily diverse fishes and the aquatic clawed toad Xenopus laevis. Both myosins are expressed in the inner ears of all species examined in this study. Myo7a localizes to hair cells, particularly the actin-rich hair bundle, in all species studied. Myo6 also localizes to hair cells, but its distribution differs between species and end organs. Myo6 is found in hair bundles of most fish and frog epithelia examined here but not in anterior and posterior utricular hair bundles of American shad. These results show that myo7a distribution is highly conserved in diverse vertebrates and suggest functional conservation as well. The finding of myo6 in fish and Xenopus hair bundles, however, suggests a novel role for this protein in anamniotic hair cells. The lack of myo6 in specific American shad utricular hair bundles indicates a unique quality of these cells among fishes, perhaps relating to ultrasound detection capability that is found in this species.

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Title: Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes
Creators: Allison B Coffin - Department of Biology, University of Maryland, College Park, MD 20742, USA
Alain Dabdoub - Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Matthew W Kelley - Section on Developmental Neuroscience, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Arthur N Popper - Department of Biology, University of Maryland, College Park, MD 20742, USA
Publication Details: Hearing research, Vol.224(1), pp.15-26
Academic Unit: Integrative Physiology and Neuroscience, Department of
Publisher: Elsevier B.V
Identifiers: 99900547141901842
Language: English
Resource Type: Journal article