Journal article
Myostatin inhibits porcine intramuscular preadipocyte differentiation in vitro
Domestic animal endocrinology, Vol.55, pp.25-31
04/2016
Handle:
https://hdl.handle.net/2376/109761
PMID: 26657406
Abstract
This study assessed the effect of myostatin on adipogenesis by porcine intramuscular preadipocytes. Intramuscular preadipocytes were isolated from the longissimus dorsi muscle of newborn pigs. Myostatin inhibited intramuscular preadipocyte differentiation in a dose-dependent manner. Myostatin treatment during preadipocyte differentiation significantly (P < 0.05) inhibited the expression of the adipogenic marker genes CCAAT/enhancer-binding protein β, CCAAT/enhancer-binding protein α, peroxisome proliferator-activated receptor γ, sterol regulatory element-binding protein-1c, fatty acid-binding protein, and adiponectin. Myostatin also significantly (P < 0.05) reduced the release of glycerol and decreased both adipose triglyceride lipase and hormone-sensitive lipase expression in intramuscular adipocytes. Our study suggests that myostatin acts as an extrinsic regulatory factor in regulating intramuscular adipogenesis.
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Details
- Title
- Myostatin inhibits porcine intramuscular preadipocyte differentiation in vitro
- Creators
- W X Sun - College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China; College of Public Health, Nantong University, Nantong, 226019, ChinaM V Dodson - Department of Animal Sciences, Washington State University, Pullman, WA, 99164-6351, USAZ H Jiang - Department of Animal Sciences, Washington State University, Pullman, WA, 99164-6351, USAS G Yu - College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, ChinaW W Chu - College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, ChinaJ Chen - College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address: jiechen@njau.edu.cn
- Publication Details
- Domestic animal endocrinology, Vol.55, pp.25-31
- Academic Unit
- Animal Sciences, Department of
- Publisher
- United States
- Identifiers
- 99900547040301842
- Language
- English
- Resource Type
- Journal article