Journal article
N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors
Bioorganic & medicinal chemistry letters, Vol.11(17), pp.2377-2380
2001
Handle:
https://hdl.handle.net/2376/115289
PMID: 11527735
Abstract
Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs. In this report, three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) together with their
N-hydroxyl derivatives were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. The guanidine containing compounds could not release NO in the presence of NOS or peroxidase. The corresponding
N-hydroxyl compounds exhibited weak NO-releasing ability under the catalyzed of NOS and good NO-releasing ability under the oxidation by horseradish peroxidase in the presence of H
2O
2. These compounds also displayed vasodilatory activity.
N-Hydroxyl derivatives of three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. These compounds displayed vasodilatory activity.
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Details
- Title
- N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors
- Creators
- Ming Xian - Department of Chemistry, Wayne State University, Detroit, MI 48202, USAXiaopeng Li - Department of Physiology, Michigan State University, East Lansing, MI 48824, USAXiaoping Tang - Department of Chemistry, Wayne State University, Detroit, MI 48202, USAXinchao Chen - Department of Chemistry, Wayne State University, Detroit, MI 48202, USAZhongling Zheng - Department of Physiology, Michigan State University, East Lansing, MI 48824, USAJames J Galligan - Department of Pharmacology, Michigan State University, East Lansing, MI 48824, USADavid L Kreulen - Department of Physiology, Michigan State University, East Lansing, MI 48824, USAPeng G Wang - Department of Chemistry, Wayne State University, Detroit, MI 48202, USA
- Publication Details
- Bioorganic & medicinal chemistry letters, Vol.11(17), pp.2377-2380
- Academic Unit
- Chemistry, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900547621301842
- Language
- English
- Resource Type
- Journal article