Nanomedicine for intracellular therapy

Ashish Ranjan; Nikorn Pothayee; Mohamed N Seleem; Stephen M Boyle; Ramanathan Kasimanickam; Judy S Riffle; Nammalwar Sriranganathan

doi:10.1111/j.1574-6968.2012.02566.x

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Nanomedicine for intracellular therapy

Ashish Ranjan, Nikorn Pothayee, Mohamed N Seleem, Stephen M Boyle, Ramanathan Kasimanickam, Judy S Riffle and Nammalwar Sriranganathan

FEMS microbiology letters, Vol.332(1), pp.1-9

07/2012

DOI: https://doi.org/10.1111/j.1574-6968.2012.02566.x

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https://hdl.handle.net/2376/105792

PMID: 22471308

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Abstract

nanoparticle

drug delivery

intracelluar infection

Intracellular pathogens like Salmonella evade host phagocytic killing by various mechanisms. Classical antimicrobial therapy requires multiple dosages and frequent administration of drugs for a long duration. Intracellular delivery of antimicrobials using nanoparticle may effectively devise therapies for bacterial infections. This review will address the mechanisms used by Salmonella to avoid host pathogenic killing, reasons for therapeutic failure and advances in nanoparticle drug delivery technology for efficient intracellular bacterial clearance.

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Title: Nanomedicine for intracellular therapy
Creators: Ashish Ranjan - National Institutes of Health
Nikorn Pothayee - Virginia Tech
Mohamed N Seleem - Purdue University
Stephen M Boyle - Virginia Tech
Ramanathan Kasimanickam - Washington State University
Judy S Riffle - Virginia Tech
Nammalwar Sriranganathan - Virginia Tech
Publication Details: FEMS microbiology letters, Vol.332(1), pp.1-9
Academic Unit: Veterinary Clinical Sciences, Department of
Number of pages: 9
Identifiers: 99900546728101842
Language: English
Resource Type: Journal article