Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy

Dafeng Chu; Qi Zhao; Jian Yu; Faya Zhang; Hui Zhang; Zhenjia Wang

doi:10.1002/adhm.201500998

Back

Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy

Journal article

Open access

Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy

Dafeng Chu, Qi Zhao, Jian Yu, Faya Zhang, Hui Zhang and Zhenjia Wang

Advanced healthcare materials, Vol.5(9), pp.1088-1093

05/2016

DOI: https://doi.org/10.1002/adhm.201500998

Handle:

https://hdl.handle.net/2376/113734

PMCID: PMC4864103

PMID: 26989887

Files and links (1)

url

https://doi.org/10.1002/adhm.201500998View

Published (Version of record) Open

Abstract

Nanoparticles - chemistry

Neutrophils - immunology

Antineoplastic Agents, Immunological - chemistry

Antineoplastic Agents, Immunological - pharmacology

Neoplasms, Experimental - pathology

Animals

Antineoplastic Agents, Immunological - immunology

Nanoparticles - therapeutic use

Immunotherapy

Neoplasms, Experimental - immunology

Mice

Neoplasms, Experimental - drug therapy

Neutrophil Infiltration - drug effects

Neutrophil Infiltration - immunology

Cancer immunotherapy using tumor-specific monoclonal antibodies presents a novel approach for cancer treatment. A monoclonal antibody TA99 specific for gp75 antigen of melanoma initiates neutrophil recruitment in tumor responsible for cancer therapy. Here, a strategy is reported for hijacking neutrophils in vivo using nanoparticles (NPs) to deliver therapeutics into tumor. In a mouse model of melanoma, it is shown that systemically delivered albumin NPs increase in tumor when TA99 antibody is injected; and the NP tumor accumulation is mediated by neutrophils. After the administration of pyropheophorbide-a loaded albumin NPs and TA99, photodynamic therapy significantly suppresses the tumor growth and increases mouse survival compared with treatment with the NPs or TA99. The study reveals a new avenue to treat cancer by NP hitchhiking of immune systems to enhance delivery of therapeutics into tumor sites.

Metrics

11 Record Views

See more details

Details

Title: Nanoparticle Targeting of Neutrophils for Improved Cancer Immunotherapy
Creators: Dafeng Chu - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA
Qi Zhao - Faculty of Health Sciences, University of Macau, Macau, China
Jian Yu - Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA
Faya Zhang - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA
Hui Zhang - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA
Zhenjia Wang - Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA, 99210, USA
Publication Details: Advanced healthcare materials, Vol.5(9), pp.1088-1093
Academic Unit: Pharmaceutical Sciences, Department of
Publisher: Germany
Grant note: K25 HL111157 / NHLBI NIH HHS R01 GM116823 / NIGMS NIH HHS
Identifiers: 99900547812801842
Language: English
Resource Type: Journal article