Journal article
Narcotic antagonist-induced hypotension in the spontaneously hypertensive rat
Life sciences (1973), Vol.37(9), pp.819-826
1985
Handle:
https://hdl.handle.net/2376/109160
PMID: 4033357
Abstract
Intravenous naloxone or naltrexone produced transient, dose-related reductions in the mean arterial pressure (MAP) and heart rate (HR) of urethane-anesthesized spontaneously hypertensive rats (SHRs). Yet these same doses of narcotic antagonists reduced HR but not MAP of normotensive Wistar-Kyoto rats (WKYs). Such effects were not observed upon administration to SHRs of increasing doses of methylnaltrexone, which possesses no central activity. (+)-Naloxone, which does not block opiate receptors, reduced HR but not MAP of both SHRs and WKYs. These findings indicate that SHRs and WKYs differ in their MAP and HR responses to narcotic antagonists. The high doses required for effect plus the brevity of the responses suggest that these drug effects are perhaps not μ-opiate receptor-mediated; however, the methylnaltrexone and (+)-naloxone findings clearly implicate a central specificity of action. We conclude that narcotic antagonist-induced changes in MAP and HR in SHRs are possibly specific and central in origin yet not mediated by μ-opiate receptors.
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Details
- Title
- Narcotic antagonist-induced hypotension in the spontaneously hypertensive rat
- Creators
- Raymond M QuockF Jay KouchichLinda K VaughnDavid S Fries - Divisions of Pharmacology and Physiology, Marquette University School of Dentistry, Milwaukee, Wisconsin 53233, USA
- Publication Details
- Life sciences (1973), Vol.37(9), pp.819-826
- Academic Unit
- Psychology, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900547107901842
- Language
- English
- Resource Type
- Journal article