Journal article
Nateglinide Therapy for Type 2 Diabetes Mellitus
The Annals of pharmacotherapy, Vol.35(11), pp.1426-1434
11/2001
Handle:
https://hdl.handle.net/2376/103039
PMID: 11724096
Abstract
OBJECTIVE:
To review the pharmacology, pharmacokinetics, dosing guidelines, adverse effects, drug interactions, and clinical efficacy of nateglinide.
DATA SOURCES:
Primary and review articles regarding nateglinide were identified by MEDLINE search (from 1966 to January 2001); abstracts were identified through the Institute for Scientific Information Web of Science (from 1995 to January 2001) and the American Diabetes Association; additional information was obtained from the nateglinide product information.
STUDY SELECTION/DATA EXTRACTION:
All articles and meeting abstracts identified from the data sources were evaluated and all information deemed relevant was included in this review. Much of the information was from abstracts or the product labeling, since few clinical studies have been published in the medical literature.
DATA SYNTHESIS:
Nateglinide is a novel nonsulfonylurea oral antidiabetic agent that stimulates insulin secretion from the pancreas. It has a rapid onset and short duration of action, allowing administration before a meal to reduce postprandial hyperglycemia. Improvement in glycemic control with nateglinide monotherapy has been demonstrated in patients not previously treated with antidiabetic medications. Greater improvement in glycemic control was observed when nateglinide was administered in combination with metformin.
CONCLUSIONS:
Nateglinide is similar to repaglinide, but has a quicker onset of action, quicker reversal, and does not usually require dosage titration. Based on the pharmacodynamics of nateglinide and repaglinide, nateglinide produces a more rapid postprandial increase in insulin secretion, and its duration of response is shorter than that of repaglinide. The risk of postabsorptive hypoglycemia should be lower than with either sulfonylureas or repaglinide.
Metrics
7 Record Views
Details
- Title
- Nateglinide Therapy for Type 2 Diabetes Mellitus
- Creators
- Terri L Levien - PharmD, Drug Information Pharmacist, College of Pharmacy, Washington State University, Spokane, WADanial E Baker - PharmD FASCP FASHP, Director, Drug Information Center, Professor of Pharmacy Practice, College of Pharmacy, Washington State University, SpokaneR Keith Campbell - BPharm MBA CDE FASHP FAPhA, Associate Dean, Professor of Pharmacy Practice, College of Pharmacy, Washington State University, Pullman, WAJohn R White - PA-C PharmD, Associate Professor of Pharmacy Practice, College of Pharmacy, Washington State University, Spokane
- Publication Details
- The Annals of pharmacotherapy, Vol.35(11), pp.1426-1434
- Academic Unit
- Pharmacotherapy, Department of
- Publisher
- SAGE Publications
- Identifiers
- 99900546789001842
- Language
- English
- Resource Type
- Journal article