Journal article
Nerve growth factor enhances sleep in rabbits
Neuroscience letters, Vol.264(1), pp.149-152
1999
Handle:
https://hdl.handle.net/2376/104637
PMID: 10320036
Abstract
Nerve growth factor (NGF) elicits rapid-eye-movement sleep (REMS) in cats. Removal of NGF receptor-positive cholinergic basal forebrain neurons inhibits REMS in rats. The aim of the present study was to determine the effects of NGF on sleep and brain temperature (Tbr) in rabbits. Male rabbits were implanted with electroencephalograph (EEG) electrodes, a brain thermistor and an intraventricular (i.c.v.) guide cannula. Rabbits received human
β-NGF i.c.v. (0.01, 0.1, 1.0 or 10
μg] and on a separate day, 25
μl pyrogen-free saline i.c.v. as control. EEG and Tbr were recorded for 23 h after injections. The highest two doses of NGF increased both non-REMS and REMS across the 23-h recording period. REMS was enhanced dose-dependently. Tbr was not affected by any dose of NGF. These results suggest that NGF is involved in both REMS and non-REMS regulation.
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Details
- Title
- Nerve growth factor enhances sleep in rabbits
- Creators
- Satoshi Takahashi - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164–6520, USAJames M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164–6520, USA
- Publication Details
- Neuroscience letters, Vol.264(1), pp.149-152
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900546944501842
- Language
- English
- Resource Type
- Journal article