Journal article
Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection
Science advances, Vol.5(11), pp.eaaw4717-eaaw4717
11/2019
Handle:
https://hdl.handle.net/2376/104926
PMCID: PMC6867885
PMID: 31799388
Abstract
Increasing evidence indicates that infection-triggered host defenses are regulated by the nervous system. However, the precise mechanisms of this regulation are not well understood. Here, we demonstrate that neuronal G protein-coupled receptor NPR-8 negatively regulates
defense against pathogen infection by suppressing cuticular collagen expression. NPR-8 controls the dynamics of cuticle structure in response to infection, likely through its regulation of cuticular collagen genes which, in turn, affects the nematode's defense. We further show that the defense activity of NPR-8 is confined to amphid sensory neurons AWB, ASJ, and AWC. It is generally believed that physical barrier defenses are not a response to infections but are part of the body's basic innate defense against pathogens. Our results challenge this view by showing not only that
cuticle structure dynamically changes in response to infection but also that the cuticle barrier defense is regulated by the nervous system.
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Details
- Title
- Neuronal GPCR NPR-8 regulates C. elegans defense against pathogen infection
- Creators
- Durai Sellegounder - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USAYiyong Liu - Genomics Core, Washington State University, Spokane, WA, USAPhillip Wibisono - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USAChia-Hui Chen - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USADavid Leap - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USAJingru Sun - Department of Biomedical Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, USA
- Publication Details
- Science advances, Vol.5(11), pp.eaaw4717-eaaw4717
- Academic Unit
- Biomedical Sciences, Department of
- Publisher
- United States
- Grant note
- R35 GM124678 / NIGMS NIH HHS
- Identifiers
- 99900546774501842
- Language
- English
- Resource Type
- Journal article