Journal article
Neurotrophins 3 and 4 enhance non-rapid eye movement sleep in rabbits
Neuroscience letters, Vol.346(3), pp.161-164
2003
Handle:
https://hdl.handle.net/2376/109658
PMID: 12853109
Abstract
We determined if neurotrophins 3 and 4 (NT-3, NT-4) would promote sleep in rabbits. Two doses of NT-3 (50 and 500 ng) and three doses of NT-4 (50, 500 and 2000 ng) were intracerebroventricularly injected at dark onset. Additionally, 500 ng of each NT were injected during the light period. The electroencephalogram (EEG), brain temperature, and motor activity were recorded for 23 h following NT injection. NT-3 (500 ng dose) and NT-4 (500 and 2000 ng doses) injected at dark onset increased the time spent in non-rapid eye movement sleep. After the 2000 ng dose of NT-4, EEG power was reduced.
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Details
- Title
- Neurotrophins 3 and 4 enhance non-rapid eye movement sleep in rabbits
- Creators
- Tetsuya Kushikata - Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036-8506, JapanTakeshi Kubota - Department of Anesthesiology, University of Hirosaki School of Medicine, Hirosaki 036-8506, JapanJidong Fang - Department of Psychiatry, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USAJames M Krueger - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164-6520, USA
- Publication Details
- Neuroscience letters, Vol.346(3), pp.161-164
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900547483701842
- Language
- English
- Resource Type
- Journal article