No Association Between Vitamin D Intake, VDR Polymorphisms, and Colorectal Cancer in a Population-Based Case-Control Study

Joseph H Ashmore; Carla J Gallagher; Samuel M Lesko; Joshua E Muscat; Terryl J Hartman; Philip Lazarus

doi:10.1158/1055-9965.EPI-15-0284

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No Association Between Vitamin D Intake, VDR Polymorphisms, and Colorectal Cancer in a Population-Based Case-Control Study

Journal article

Open access

Peer reviewed

No Association Between Vitamin D Intake, VDR Polymorphisms, and Colorectal Cancer in a Population-Based Case-Control Study

Joseph H Ashmore, Carla J Gallagher, Samuel M Lesko, Joshua E Muscat, Terryl J Hartman and Philip Lazarus

Cancer epidemiology, biomarkers & prevention, Vol.24(10), pp.1635-1637

10/2015

DOI: https://doi.org/10.1158/1055-9965.EPI-15-0284

Handle:

https://hdl.handle.net/2376/107455

PMID: 26224799

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https://doi.org/10.1158/1055-9965.EPI-15-0284View

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Abstract

Colorectal Neoplasms - epidemiology

Follow-Up Studies

Colorectal Neoplasms - genetics

Gene Frequency

Humans

Middle Aged

Risk Factors

Male

Receptors, Calcitriol - metabolism

Receptors, Calcitriol - genetics

Incidence

Polymorphism, Genetic

Dose-Response Relationship, Drug

Female

Vitamin D - administration & dosage

Aged

Retrospective Studies

DNA, Neoplasm - genetics

Pennsylvania - epidemiology

Population Surveillance

Colorectal Neoplasms - metabolism

Vitamins - administration & dosage

Epidemiologic evidence indicates that greater intakes of vitamin D may decrease the risk of colorectal cancer. Variants in the vitamin D receptor (VDR) gene have the potential to modify associations between vitamin D intake and colorectal cancer. Associations between intakes of vitamin D and colorectal cancer were studied in a large case-control study conducted in central and northeastern Pennsylvania including 1,012 cases with histologically confirmed colorectal cancer and 1,080 population-based controls. Associations between 35 tagSNPs encompassing the VDR gene and risk for colorectal cancer as well as gene-diet associations were also assessed among a subset of the population (770 controls, 710 cases). No significant trends were observed between vitamin D intake and colorectal cancer risk. After adjustment for multiple comparisons, none of the SNPs or haplotypes within the VDR gene were associated with colorectal cancer. There were also no interactions between dietary factors and variants in the entire VDR gene. Overall, results from this study suggest that vitamin D intake and variants in the VDR gene have little effect on risk for colorectal cancer. Increasing vitamin D intake from the diet may not result in decreasing the incidence of colorectal cancer.

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Title: No Association Between Vitamin D Intake, VDR Polymorphisms, and Colorectal Cancer in a Population-Based Case-Control Study
Creators: Joseph H Ashmore - Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington
Carla J Gallagher - Department of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania. Department of Pharmacology, Pennsylvania State College of Medicine, Hershey, Pennsylvania
Samuel M Lesko - Northeast Regional Cancer Institute, Scranton, Pennsylvania. The Commonwealth Medical College, Scranton, Pennsylvania
Joshua E Muscat - Department of Public Health Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania
Terryl J Hartman - Department of Epidemiology, Rollins School of Public Health, and Winship Cancer Institute, Emory University, Atlanta, Georgia
Philip Lazarus - Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington. phil.lazarus@wsu.edu
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.24(10), pp.1635-1637
Academic Unit: Pharmaceutical Sciences, Department of
Publisher: United States
Identifiers: 99900546880701842
Language: English
Resource Type: Journal article