Journal article
Noise-induced elevations of plasma endothelin (ET-3)
Hearing research, Vol.80(1), pp.119-122
1994
Handle:
https://hdl.handle.net/2376/114652
PMID: 7852197
Abstract
The endothelins (ETs) are a novel family of peptides which participate in hemodynamic homeostasis. Elevated levels of circulating ETs are evident in several stress related conditions and are associated with a variety of vascular pathophysiologics. The purpose of the current study was to test the possibility that plasma concentrations of endothelin increase following noise exposure using radioimmunoassay (RIA). No difference in plasma endothelin was detected in rats subjected to brief noise exposure (30 min of 100 dB SPL broad-band noise) compared to control animals. Statistically significant elevations in plasma endothelin (ET-3) were measured in animals exposed to prolonged noise exposure (90 min and 72 h of 100 dB SPL broad-band noise). These results suggest that hemodynamic alterations, and potential vascular pathophysiologies accompanying prolonged exposure to noise are mediated by endothelin.
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Details
- Title
- Noise-induced elevations of plasma endothelin (ET-3)
- Creators
- Wayne S Quirk - Department of Otolaryngology, Microcirculation Laboratory, 5E UHC, East Canfield, Wayne State University Detroit, MI 48201 USAJohn K.M Coleman - Kresge Hearing Research Institute, The University of Michigan Ann Arbor, MI 48109-0506 USAJ.M Hanesworth - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University Pullman, WAUSAJoseph W Harding - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University Pullman, WAUSAJohn W Wright - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University Pullman, WAUSA
- Publication Details
- Hearing research, Vol.80(1), pp.119-122
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier B.V
- Identifiers
- 99900548079501842
- Language
- English
- Resource Type
- Journal article