Journal article
Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system
Neuroscience letters, Vol.220(2), pp.97-100
1996
Handle:
https://hdl.handle.net/2376/105679
PMID: 8981482
Abstract
Sleep-wake activity was studied in a transgenic mouse model (TH-hGH) with a deficiency in the somatotropic axis (growth hormone (GH)-releasing hormone (GHRH)-GH-insulin-like growth factor-I (IGF-I)). This dwarf transgenic mouse strain expresses a human GH (hGH) reporter gene linked to 4.8 kb of the rat tyrosine hydroxylase flanking sequence, targeting the production of hGH to sites of tyrosine hydroxylase synthesis in the brain. Endogenous GH and IGF-I are supressed in these mice, as well as GHRH. Sleep-wake activity (EEG and EMG) was recorded for 2 to 3 days in nine transgenic mice and nine wild-type littermates. Non-rapid eye movement sleep (NREMS) was significantly suppressed during both the light and the dark period in the transgenic mice; rapid eye movement sleep (REMS) was not altered. The results provide evidence that the somatotropic axis contributes to normal sleep regulation.
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Details
- Title
- Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system
- Creators
- Jianyi Zhang - Department of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USAFerenc Obál - Department of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USAJidong Fang - Department of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USABarbara J Collins - Section of Endocrinology, University of Illinois, Chicago, IL, USAJames M Krueger - Department of Physiology and Biophysics, University of Tennessee, 894 Union Avenue, Memphis, TN 38163, USA
- Publication Details
- Neuroscience letters, Vol.220(2), pp.97-100
- Academic Unit
- Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Ireland Ltd
- Identifiers
- 99900546877601842
- Language
- English
- Resource Type
- Journal article