Journal article
Nonlinear Myofilament Regulatory Processes Affect Frequency-Dependent Muscle Fiber Stiffness
Biophysical journal, Vol.81(4), pp.2278-2296
2001
Handle:
https://hdl.handle.net/2376/114224
PMCID: PMC1301699
PMID: 11566798
Abstract
To investigate the role of nonlinear myofilament regulatory processes in sarcomeric mechanodynamics, a model of myofilament kinetic processes, including thin filament on–off kinetics and crossbridge cycling kinetics with interactions within and between kinetic processes, was built to predict sarcomeric stiffness dynamics. Linear decomposition of this highly nonlinear model resulted in the identification of distinct contributions by kinetics of recruitment and by kinetics of distortion to the complex stiffness of the sarcomere. Further, it was established that nonlinear kinetic processes, such as those associated with cooperative neighbor interactions or length-dependent crossbridge attachment, contributed unique features to the stiffness spectrum through their effect on recruitment. Myofilament model-derived sarcomeric stiffness reproduces experimentally measured sarcomeric stiffness with remarkable fidelity. Consequently, characteristic features of the experimentally determined stiffness spectrum become interpretable in terms of the underlying contractile mechanisms that are responsible for specific dynamic behaviors.
Metrics
8 Record Views
Details
- Title
- Nonlinear Myofilament Regulatory Processes Affect Frequency-Dependent Muscle Fiber Stiffness
- Creators
- Kenneth B Campbell - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99163Maria V Razumova - Department of Physiology, University of Wisconsin–Madison, Madison, Wisconsin 53706 USARobert D Kirkpatrick - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99163Bryan K Slinker - Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99163
- Publication Details
- Biophysical journal, Vol.81(4), pp.2278-2296
- Academic Unit
- Veterinary Medicine, College of; Integrative Physiology and Neuroscience, Department of
- Publisher
- Elsevier Inc
- Identifiers
- 99900548290701842
- Language
- English
- Resource Type
- Journal article