Journal article
Norleucine1-Angiotensin IV alleviates mecamylamine-induced spatial memory deficits
Peptides (New York, N.Y. : 1980), Vol.25(2), pp.233-241
02/2004
Handle:
https://hdl.handle.net/2376/115645
PMID: 15063004
Abstract
The brain angiotensin AT4 receptor subtype has been implicated in cognitive processing. We initially established that intracerebroventricular administration of the nAChR-antagonist mecamylamine (mec) interfered with spatial memory performance in male Sprague-Dawley rats. Next we demonstrated that mec-induced deficits in spatial memory were overcome by the AT4 receptor-agonist Norleucine1-Angiotensin IV (Nle1-Ang IV). Nle1-Ang IV could not, however, compensate for spatial learning impairments precipitated by both mec and the mAChR-antagonist scopolamine. These findings support the importance of the AT4 receptor in cognitive processing and suggest that the ability of Nle1-Ang IV to improve spatial memory deficiencies may be dependant upon the brain cholinergic system.
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Details
- Title
- Norleucine1-Angiotensin IV alleviates mecamylamine-induced spatial memory deficits
- Creators
- Mikel L Olson - Department of Psychology, Washington State University, Pullman, WA 99164-4820, USAEmily A OlsonJacob H QuallsJessica J StrattonJoseph W HardingJohn W Wright
- Publication Details
- Peptides (New York, N.Y. : 1980), Vol.25(2), pp.233-241
- Academic Unit
- Psychology, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- United States
- Identifiers
- 99900547686501842
- Language
- English
- Resource Type
- Journal article