Journal article
Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages
Biomaterials, Vol.222(C), pp.119398-119398
11/2019
Handle:
https://hdl.handle.net/2376/105756
PMID: 31487582
Abstract
Hydrogen sulfide (H2S), as a gaseous messenger, exhibits potential therapeutic effects in biological and clinical applications. Herein, an in situ forming biomimetic hyaluronic acid (HA) hydrogel was used as a matrix to dope a pH-controllable H2S donor, JK1, to form a novel HA-JK1 hybrid system. This HA-JK1 hydrogel was designed as an ideal delivery scaffold for JK1 with pH-dependent prolonged H2S releasing profile. In vitro study suggested that JK1 could induce the polarization of M2 phenotype indicating a higher pro-healing efficiency of macrophages. The in vivo studies on dermal wounds showed that the HA-JK1 hybrid hydrogel significantly accelerated the wound regeneration process through enhanced re-epithelialization, collagen deposition, angiogenesis and cell proliferation. Furthermore, the in vivo results also demonstrated a higher level of M2 polarization in HA-JK1 treated group with reduced inflammation and improved wound remodeling effects, which was consistent with the in vitro results. These observations could be considered as a key to the efficient wound treatment. Therefore, we suggest that HA-JK1 can be used as a novel wound dressing material toward cutaneous wound model in vivo. This system should significantly enhance wound regeneration through the release of H2S that induces the expression of M2 macrophage phenotype.
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Details
- Title
- Novel H2S-Releasing hydrogel for wound repair via in situ polarization of M2 macrophages
- Creators
- Jiang Wu - School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaAnqi Chen - School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaYajiao Zhou - School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaSen Zheng - School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaYao Yang - College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang, 325027, PR ChinaYing An - School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaKe Xu - School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaHuacheng He - College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, Zhejiang, 325027, PR ChinaJianming Kang - Department of Chemistry, Washington State University, Pullman, WA, 99164, United StatesJittima Amie Luckanagul - Research Unit for Plant-produced Pharmaceuticals and the Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, 254 Phayathai Rd., Wangmai, Pathumwan, Bangkok, 10330, ThailandMing Xian - Department of Chemistry, Washington State University, Pullman, WA, 99164, United StatesJian Xiao - School of Pharmaceutical Sciences, Key Laboratory of Biotechnology and Pharmaceutical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, ChinaQian Wang - Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, 29208, United States
- Publication Details
- Biomaterials, Vol.222(C), pp.119398-119398
- Academic Unit
- Chemistry, Department of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546833301842
- Language
- English
- Resource Type
- Journal article